Recombinant Rat CD95 Protein (aa 1-170) [His] (VAng-Cr3937)

Recombinant Rat CD95 Protein (Met 1-Lys 170) fused with a His tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 18 kDa. (Accession ID: NP_631933.2)

Datasheet

Specifications

Source

Rat

Target

CD95

Type

Tumor Antigens

Applications

ELISA.

Formulation

Lyophilized from sterile PBS, pH 7.4.

Purity

> 90% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

CD95 is an important inducer of the extrinsic apoptosis signaling pathway. FAS receptor is located on the long arm of chromosome 10 (10q24.1) in humans and on chromosome 19 in mice. The gene lies on the plus (Watson strand) and is 25,255 bases in length organised into nine protein encoding exons. Previous reports have identified as many as eight splice variants, which are translated into seven isoforms of the protein. Apoptosis-inducing Fas receptor is dubbed isoform 1 and is a type 1 transmembrane protein. Many of the other isoforms are rare haplotypes that are usually associated with a state of disease. However, two isoforms, the apoptosis-inducing membrane-bound form and the soluble form, are normal products whose production via alternative splicing is regulated by the cytotoxic RNA binding protein TIA1. It has 319 amino acids, has a predicted molecular weight of 48 kiloDaltons and is divided into 3 domains: an extracellular domain, a transmembrane domain, and a cytoplasmic domain. The extracellular domain has 157 amino acids and is rich in cysteine residues.

Alternative Names

FAS; ALPS1A; APO-1; APT1; FAS1; FASTM; TNFRSF6