Recombinant Rat PD-L1 Protein (aa 1-238) [Fc] (VAng-Cr4036)

Recombinant Rat PD-L1 Protein (Met1-Thr238) fused with a Fc tag at C-terminus was expressed in HEK293 Cells, with a molecular weight of 51.8 kDa. (Accession ID: NP_001178883.1)

Datasheet

Specifications

Source

Rat

Target

PD-L1

Type

Tumor Antigens

Applications

ELISA.

Formulation

Lyophilized from sterile PBS, pH 7.4.

Purity

> 95% pure by SDS-PAGE.

Storage

Store at -20°C to -80°C.

Antigen Information

Introduction

PD-L1 is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. Normally the immune system reacts to foreign antigens that are associated with exogenous or endogenous danger signals, which triggers a proliferation of antigen-specific CD8+ T cells and/or CD4+ helper cells. The binding of PD-L1 to PD-1 or B7.1 transmits an inhibitory signal that reduces the proliferation of antigen-specific T-cells in lymph nodes, while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells). PD-L1 binds to its receptor, PD-1, found on activated T cells, B cells, and myeloid cells, to modulate activation or inhibition. It appears that upregulation of PD-L1 may allow cancers to evade the host immune system.

Alternative Names

CD274; B7-H; B7H1; PDCD1L1; PDCD1LG1; PDL1; CD274 molecule; Programmed cell death 1 ligand 1