Recombinant SIRP alpha Protein (Met 1-Arg 370) [His] (VAng-Cr3847)
Recombinant SIRP alpha Protein (Met 1-Arg 370) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 45-50 kDa. (Uniprot ID: P78324)
Datasheet
Specifications
Source
Mammalian cells
Target
SIRP alpha
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
SIRP alpha is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons. SIRP alpha acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47. This interaction negatively controls effector function of innate immune cells such as host cell phagocytosis. SIRP alpha diffuses laterally on the macrophage membrane and accumulates at a phagocytic synapse to bind CD47 and signal 'self', which inhibits the cytoskeleton-intensive process of phagocytosis by the macrophage. This is analogous to the self signals provided by MHC class I molecules to NK cells via Ig-like or Ly49 receptors. NB. Protein shown to the right is CD47 not SIRP alpha.
Alternative Names
SIRPA; BIT; CD172A; MFR; MYD-1; P84; PTPNS1; SHPS1; SIRP
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