Recombinant TIM-3 Protein (Met1-Arg200) [His] (VAng-Cr3838)
Recombinant TIM-3 Protein (Met1-Arg200) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 40 kDa. (Uniprot ID: Q8TDQ0)
Datasheet
Specifications
Source
Mammalian cells
Target
TIM-3
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
TIM-3 is a protein that in humans is encoded by TIM-3 gene. It is first described as a cell surface molecule expressed on IFN gamma producing CD4+ Th1 and CD8+ Tc1 cells. Later, the expression is detected in Th17 cells, regulatory T-cells, and innate immune cells (dendritic cells, NK cells, monocytes). It belongs to TIM family cell surface receptor proteins. These proteins share a similar structure, in which the extracellular region consists of membrane distal single variable immunoglobulin domain (IgV) and a glycosylated mucin domain of variable length located closer to the membrane.
Alternative Names
HAVCR2; HAVcr-2; KIM-3; TIM3; TIMD-3; TIMD3; Tim-3; CD366; hepatitis A virus cellular receptor 2
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