Recombinant TNFRSF8 Protein (Met1-Lys379) [His] (VAng-Cr3774)
Recombinant TNFRSF8 Protein (Met1-Lys379) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 75-90 kDa. (Uniprot ID: P28908)
Datasheet
Specifications
Source
Mammalian cells
Target
TNFRSF8
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
TNFRSF8 is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappa B. It is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. It is expressed in embryonal carcinoma but not in seminoma and is thus a useful marker in distinguishing between these germ cell tumors.
Alternative Names
TNFRSF8; CD30; D1S166E
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
