Recombinant TNFRSF9 Protein (Met1-Gln186) [His] (VAng-Cr3814)
Recombinant TNFRSF9 Protein (Met1-Gln186) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 30 kDa. (Uniprot ID: Q07011)
Datasheet
Specifications
Source
Mammalian cells
Target
TNFRSF9
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
TNFRSF9 is a member of the tumor necrosis factor (TNF) receptor family. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule. It can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, B cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. The best characterized activity of CD137 is its costimulatory activity for activated T cells. Crosslinking of CD137 enhances T cell proliferation, IL-2 secretion, survival and cytolytic activity.
Alternative Names
CD137; ILA; 4-1BB
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