Recombinant VISTA Protein (Met1-Ala194) [His] (VAng-Cr3824)
Recombinant VISTA Protein (Met1-Ala194) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 21.34 kDa. (Uniprot ID: Q9H7M9)
Datasheet
Specifications
Source
Mammalian cells
Target
VISTA
Type
Tumor Antigens
Applications
SDS-PAGE; WB; ELISA.
Formulation
Protein lyophilized in sterile PBS/Protein store in sterile PBS.
Purity
> 90% pure by SDS-PAGE.
Storage
Store at -20 °C to -80 °C.
Antigen Information
Introduction
VISTA is a protein which in humans is encoded by VISTA gene. Diseases associated with VISTA include Parasagittal Meningioma and Solar Retinopathy. Among its related pathways are NF-kappa B Signaling and T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. It is approximately 50 kDa and belongs to the immunoglobulin superfamily and has one IgV domain. It is produced at high levels in tumor-infiltrating lymphocytes, such as myeloid-derived suppressor cells and regulatory T cells, and its blockade with an antibody results in delayed tumor growth in mouse models of melanoma and squamous cell carcinoma.
Alternative Names
C10orf54; SISP1
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