Salmonella enteritidis Vaccines

Creative Biolabs is a world leader in the field of bacterial vaccine development. With our extensive experience and advanced platform, we are therefore confident in offering the best services for vaccine development against disease caused by Salmonella enteritidis and guarantee the finest results for our customers all over the world.

Salmonella Enteritidis Vaccines - Creative Biolabs

Salmonella enteritidis (S. enteritidis) is a bacterium that causes the food-borne salmonellosis pandemic in humans over the last 20 years, in part because it has the unique ability to contaminate eggs without causing discernible illness in the birds. A person after exposure to the bacteria by consuming a contaminated food or beverage, symptoms start an average of 12 to 72 hours include fever, abdominal cramps, and diarrhea. The infection route of S. enteritidis to humans involves colonization, survival and multiplication of the pathogen in the hen house environment, the bird and, finally, the egg. S. enteritidis is currently the only Salmonella serotype that causes frequent human illness associated with egg contamination, which determines its unique threat to food safety.

Live S. enteritidisVaccines

There is a modified-live vaccine which aids in the reduction of S. enteritidis, S. heidelberg and S. typhi colonization. It can help reduce colonization of a variety of Salmonella types and is proven to be safe for hatchery use. Moreover, it helps stimulate cell-mediated immunity and is effective for helping prime the immune system. In addition, a novel attenuated S. enteritidis vaccine candidate has been developed. Chickens were immunized through oral and intramuscular routes to reduce egg contamination against S. enteritidis challenge. The immunized groups showed significantly high plasma IgG and intestinal secretory IgA levels and the egg contamination rates were significantly lower in the 1st, 2nd and 3rd weeks post-challenge. Booster immunizations with this vaccine candidate, especially via oral administration route, showed an efficient protection against internal egg contamination with S. enteritidis.

Inactivated S. enteritidis Vaccines

The S. enteritidis inactivated vaccines are available that helps reduce colonization by S. enteritidis. One of them contains the most three common S. enteritidis phage types, including 8, 13a, and the highly pathogenic phage type 4. These vaccines are characterized by their high antigenic concentration and capacity to stimulate the production of specific antibodies (humoral immunity) in the hen. Immunoglobulin G is found at high concentrations in the yolk, providing some protection against internal S. enteritidis contamination. The inactivated vaccine prompted a reduction in the percentage of several leucocyte subsets after the boost dose. Compared with live vaccine, the inactivated vaccine stimulates higher titers in a shorter period.

Combination Vaccine

There is a combination vaccine that aids in the reduction of S. enteritidis colonization of the internal organs and also aids in the prevention of the signs and lesions associated with Newcastle disease and infectious bronchitis. The vaccine contains three inactivated S. enteritidis phage types including 8, 13a, and the highly pathogenic phage type 4 to help prevent egg-borne Salmonella contamination.

Creative Biolabs is a highly proactive, robust, and diversified company with a strong, scientifically-proven background of bacterial vaccine development. We have experts who are able to help you with the vaccine development against typhoid fever caused by Salmonella enteritidis. If you are interested in our services, please contact us for more details.


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