CD40LG

CD40LG is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 (protein) on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells (TFH cells). On TFH cells, CD154 promotes B cell maturation and function by engaging CD40 on the B cell surface and therefore facilitating cell-cell communication. A defect in this gene results in an inability to undergo immunoglobulin class switching and is associated with hyper IgM syndrome. Absence of CD154 also stops the formation of germinal centers and therefore prohibiting antibody affinity maturation, an important process in the adaptive immune system.

CAT Product Name Source Product Overview Target Type Datasheet Size Price
VAng-Cr3810 Recombinant CD40LG Protein (Glu108-Leu261) [His] Mammalian cells Recombinant CD40LG Protein (Glu108-Leu261) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 18 kDa. (Uniprot ID: P29965) CD40LG Tumor Antigens Datasheet 100 µg Inquiry
VAng-1302Lsx Recombinant CD40 Ligand Protein (Glu 108-Leu 261) [His] HEK293 Cells. Human CD40 Ligand, His tag, is expressed in HEK 293 cells. (Uniprot ID: P29965-1) CD40LG Tumor Antigens Datasheet 100 µg Inquiry
VAng-1303Lsx Recombinant CD40 Ligand Protein (Glu 108-Leu 261) [His] [Avi] HEK293 Cells. Biotinylated Human CD40 Ligand, His tag and Avi tag, is expressed in HEK 293 cells. (Uniprot ID: P29965-1) CD40LG Tumor Antigens Datasheet 25 µg Inquiry
VAng-1304Lsx Recombinant CD40 Ligand Protein (Gly 115-Leu 260) [Fc] HEK293 Cells. Mouse CD40 Ligand, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: P27548) CD40LG Tumor Antigens Datasheet 100 µg Inquiry
VAng-1305Lsx Recombinant CD40 Ligand Protein (Gly 115-Leu 260) [His] HEK293 Cells. Mouse CD40 Ligand, His tag, is expressed in HEK 293 cells. (Uniprot ID: P27548) CD40LG Tumor Antigens Datasheet 100 µg Inquiry
VAng-1306Lsx Human / Rhesus macaque CD40 Ligand Protein (Met 113-Leu 261) [Fc] HEK293 Cells. Human / Rhesus macaque CD40 Ligand, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: P29965-1) CD40LG Tumor Antigens Datasheet 100 µg Inquiry
VAng-1307Lsx Biotinylated Human CD40 Ligand Protein (Met 113-Leu 261) [Fc] HEK293 Cells. Biotinylated Human CD40 Ligand, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: P29965-1) CD40LG Tumor Antigens Datasheet 25 µg Inquiry
VAng-1308Lsx Human CD40 Ligand Protein (Met 113-Leu 261) [Fc] HEK293 Cells. Human CD40 Ligand, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: P29965-1) CD40LG Tumor Antigens Datasheet 100 µg Inquiry

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