HAVCR2

HAVCR2 is a protein that in humans is encoded by HAVCR2 gene. HAVCR2 belongs to TIM family cell surface receptor proteins. These proteins share a similar structure, in which the extracellular region consists of membrane distal single variable immunoglobulin domain (IgV) and a glycosylated mucin domain of variable length located closer to the membrane. Intracellular domain of HAVCR2 is called C-terminal cytoplasmic tail. It contains five conserved tyrosine residues that interact with multiple components of T-cell receptor (TCR) complex and negatively regulates its function. HAVCR2 is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein (LAG3) mediate the CD8+ T-cell exhaustion.

CAT Product Name Source Product Overview Target Type Datasheet Size Price
VAng-Cr3813 Recombinant HAVCR2 Protein (Met1-Arg200) [His] Mammalian cells Recombinant HAVCR2 Protein (Met1-Arg200) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 40 kDa. (Uniprot ID: Q8TDQ0) HAVCR2 Tumor Antigens Datasheet 100 µg Inquiry

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