ICOS

ICOS is a CD28-superfamily costimulatory molecule that is expressed on activated T cells. It is thought to be important for Th2 cells in particular. The protein encoded by ICOS gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses and regulation of cell proliferation. The increase served as a pharmacodynamic biomarker of anti-CTLA-4 treatment. An agonistic stimulus for the ICOS pathway during anti-CTLA-4 therapy resulted in an increase in efficacy that is about four to five times as large as that of control treatments.

CAT Product Name Source Product Overview Target Type Datasheet Size Price
VAng-Cr3811 Recombinant ICOS Protein (Met1- Lys140) [Fc] Mammalian cells Recombinant ICOS Protein (Met1- Lys140) fused with a Fc tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 45 kDa. (Uniprot ID: Q9Y6W8) ICOS Tumor Antigens Datasheet 100 µg Inquiry
VAng-Cr3842 Recombinant ICOS Protein (Met1- Lys140) [His] Mammalian cells Recombinant ICOS Protein (Met1- Lys140) fused with a Fc tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 45 kDa. (Uniprot ID: Q9Y6W8) ICOS Tumor Antigens Datasheet 100 µg Inquiry
VAng-1734Lsx Human ICOS Protein (Glu 21-Leu 144) [Fc] HEK293 Cells. Human ICOS (CD278), Fc Tag, is expressed in human 293 cells. (Uniprot ID: Q9Y6W8-1) ICOS Tumor Antigens Datasheet 100 µg Inquiry
VAng-1735Lsx Human ICOS Protein (Glu 21-Phe 141) [His] HEK293 Cells. Human ICOS (CD278), His tag, is expressed in human 293 cells. (Uniprot ID: Q9Y6W8-1) ICOS Tumor Antigens Datasheet 100 µg Inquiry
VAng-1736Lsx Human ICOS Protein (Glu 21-Phe 141) [His] [Avi] HEK293 Cells. Biotinylated Human ICOS (CD278), His tag and Avi tag, is expressed in human 293 cells. (Uniprot ID: Q9Y6W8-1) ICOS Tumor Antigens Datasheet 25 µg Inquiry
VAng-1926Lsx Mouse ICOS Protein (Glu 21-Leu 144) [Fc] HEK293 Cells. Mouse ICOS (CD278), Fc Tag, is expressed in human 293 cells. (Uniprot ID: Q9WVS0-1) ICOS Tumor Antigens Datasheet 100 µg Inquiry
VAng-1927Lsx Mouse ICOS Protein (Glu 21-Leu 144) [His] HEK293 Cells. Mouse ICOS (CD278), His Tag, is expressed in human 293 cells. (Uniprot ID: Q9WVS0-1) ICOS Tumor Antigens Datasheet 100 µg Inquiry

All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.

Shopping Basket