S100B

S100B (S100 Calcium Binding Protein B) is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.

CAT Product Name Source Product Overview Target Type Datasheet Size Price
VAng-2678Lsx Human S100B Protein (Met 1-Glu 92) [His] E. coli Human S100B protein was expressed in E. coli. (Uniprot ID: NP_006263) S100B Tumor Antigens Datasheet 100 µg Inquiry

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