TIGIT

TIGIT is an immune receptor present on some T cells and Natural Killer Cells (NK). It is also identified as WUCAM and Vstm3. TIGIT could bind to CD155 (PVR) on dendritic cells (DCs), macrophages, with high affinity, and also to CD112(PVRL2) with lower affinity. TIGIT-Fc fusion protein could interact with PVR on dendritic cells and increase its IL-10 secretion level/decrease its IL-12 secretion level under LPS stimulation, and also inhibit T cell activation. TIGIT's inhibition of NK cytotoxicity can be blocked by antibodies against its interaction with PVR and the activity is directed through its ITIM domain.

CAT Product Name Source Product Overview Target Type Datasheet Size Price
VAng-Cr3848 Recombinant TIGIT Protein (Met1-Pro141) [His] Mammalian cells Recombinant TIGIT Protein (Met1-Pro141) fused with a His tag at C-terminus was expressed in Mammalian cells, with a molecular weight of 13.99 kDa. (Uniprot ID: Q495A1) TIGIT Tumor Antigens Datasheet 100 µg Inquiry

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