Vaccines for Rinderpest Virus
Several factors related to the virulence, pathology, and epidemiology of rinderpest are believed to be beneficial to the eradication of rinderpest. The vaccine is used extensively across the developing world to vaccinate cattle against RPV and proved to be a highly effective tool in the eradication of rinderpest.
Rinderpest Virus
Rinderpest virus (RPV) is an enveloped single-stranded negative-sense RNA virus belonging to the genus Morbillivirus within the family Paramyxoviridae. RPV is highly contagious and can cause severe diarrhea with high mortality in cattle, buffalo, sheep, goats, pigs, and other species. Therefore, it is considered to be one of the most important pathogens in the world for wild and livestock animals. Although the year 2011 saw the final declaration of the global eradication of rinderpest, that is not to say that RPV itself has gone from the world. It is well known that many laboratories have wild-type RPV isolates, and the accidental release of RPV from the laboratory is considered to be the most likely route for the virus to re-enter the environment. Efforts are continuing to limit the distribution of live viruses around the world and to prepare for the re-emergence of this disease, whether by intentional release or accidental release.
Vaccines for Rinderpest Virus
- Inactivated Vaccines
Early inactivated vaccines are produced by infected bovine tissues that were chemically inactivated. Field applications of inactivated RPV vaccines successfully cleared RPV from several countries, including Iran, the Philippines, Sri Lanka, Thailand, and Russia. However, the immunity produced by these inactivated vaccines is transient, and therefore, live attenuated vaccine strains have been developed after multiple passages in different hosts.
- Live Attenuated Vaccines
Due to the lack of susceptible cell lines for virus culture, early attempts to attenuate viruses in tissue culture have been hampered. After repeated passages in primary calf kidney cultures, RPV virulent strains have reduced virulence and are completely attenuated and are unable to cause disease in the most susceptible cattle breeds. Tissue cultured burdock vaccines can elicit long-term neutralizing antibody responses with protection from challenge several years after vaccination without causing any adverse effects. One of the problems with the existing rinderpest vaccine is that it is serologically indistinguishable from which animals have recovered from the disease and which have been vaccinated; in other words, there is no acceptable DIVA vaccine (the ability to Distinguish Infected from Vaccinated Animals). In order to find alternative vaccines that can replace traditional live attenuated RPV strains, it has been found that the related morbillivirus virus wild-type Peste des petits ruminant virus (PPRV) protects cattle from RPV attacks and produces significant anti-RPV antibodies and RPV. Specific T cell response. There are well-established tests that distinguish between anti-RPV and anti-PPRV antibodies, so it is possible to clearly distinguish between RPV-infected and PPRV-inoculated animals.
Our Services for Rinderpest Virus Vaccine
- Isolation and passage of the virus
- Cell and tissue culture
- Inactivation of the virus
The rinderpest virus has been eradicated globally by providing the availability of a safe and effective live attenuated vaccine and a suitable companion diagnostic test. Creative Biolabs has an advanced vaccine platform to provide a variety of vaccine development and production to customers around the world.
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
