Vaccines for Virus from Filoviridae Family

Creative Biolabs is a world leader in the field of viral vaccine development. With our strong expertise and advanced platform in vaccine field, we are therefore confident in offering the best vaccine development services for different types of diseases caused by virus from Filoviridae family, including Ebola virus and Marburg Virus. We guarantee the finest results for our customers all over the world.

The viruses of Filoviridae family include Marburg virus and Ebola virus which can cause severe hemorrhagic fever in humans and nonhuman primates. Filoviruses are pantropic, producing lesions in nearly every organ and the most affected are the liver and spleen. Structure characteristics of these viruses are enveloped filamentous virions, sometimes branched filaments, as well as shorter filaments shaped like a “6”, a “U”, or a circle, 80 nm in diameter and varying greatly in length, with large peplomers, surrounding a helical nucleocapsid. Virions comprise of a central core that formed by a nucleocapsid or ribonucleoprotein (RNP) complex.

Structure of Filovirus.

Fig. 1 Structure of Filovirus.

Besides a genomic RNA molecule, there have four virion-associated structural proteins such as NP (nucleoprotein), VP35 (RNA-dependent RNA polymerase cofactor), VP30 (transcriptional activator), and L (RNA-dependent RNA polymerase) which are formed to Filovirus RNP complexes. Other three proteins are membrane-associated include GP (spike glycoprotein), VP40, and VP24 (primary and secondary matrix proteins). The first stage of replication is attachment of the GP protein to cell receptors. Following GP binding, the virions enter the host cell by way of endocytosis, after which transcription and translation of the viral RNA occur leading to a buildup of viral proteins. It is speculated that this rise in protein levels then, in turn, triggers the replication process resulting in synthesis and capsidation of negative-sense RNA molecules. These newly formed virions then attach to the cell, which initiates the budding process, and are released.

Schematic diagram showing the replication cycle of coronavirus.

Fig 2. Schematic diagram showing the replication cycle of Filovirus.

Ebola Vaccines

Ebola virus disease (EVD) is a viral hemorrhagic fever of humans and other primates caused by ebolaviruses which emerged at unprecedented epidemic levels in West Africa in 2014. Ebolavirus contains single-stranded, negative-sense RNA genome and is comprised of five species, Bundibugyo (BDBV), Reston (RESTV), Sudan (SUDV), Taï Forest (TAFV) and Ebola virus, Zaire ebolavirus (EBOV), respectively.

There are several types of Ebola vaccine candidates which are under development to protect people from EVD. These include DNA Ebola vaccine, Ebola virus-like particles, and recombinant viral vectors vaccine. The effectiveness of vaccines to be approved on the basis of animal model that replicate human disease, combined with evidence of safety and a potentially potent immune response after vaccination. Three kinds of vaccines have its own superiority in safety or immunization and can be the candidates to against EVD.

Marburg Virus Vaccines

Marburg virus is a hemorrhagic fever virus and causes a severe illness of humans and non-human primates. The typical hemorrhagic manifestations by Marburg virus disease (MVD) are maculopapular rash, petechiae, purpura, ecchymoses, and hematomas. Marburg is an extremely rare and contagious virus which is similar in symptoms and deadliness to Ebola. Complications of MVD are eye, nerve, and bleeding problems. With its contagiousness, the virus can cause an epidemic if left to spread beyond initial outbreak areas. A suitable vaccine is an effective way to prevent MVD. We provide vaccine development services for our customers, including DNA vaccines, recombinant viral vectors vaccine, and virus-like particle (VLP)-based vaccine, all of which could protect nonhuman primates from marburgvirus-induced disease.

Creative Biolabs can offer high-quality customized services by adjusting protocols to meet even the most specific requirements. We are pleased to share our cutting-edge technology and extensive expertise in the field of viral vaccine development and have focused on the Filoviridae family for years. If you are interested in our services, please contact us for more details.

Reference

  1. Ilhem Messaoudi. (2015). “Filovirus pathogenesis and immune evasion: insights from Ebola virus and Marburg virus.” Nature Reviews Microbiology. 13, 663-676.

Our services are for research use only. We do not provide services directly to individuals.

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