Whole Inactivated Yeast Based T-Cell Vaccines

As the number one killer of human health, conquering cancer has become a major issue for doctors and researchers around the world. Vaccines have been proven to have significant effects on the prevention of infectious diseases, and studies have shown that they have promising prospects for cancer prevention and treatment. Creative Biolabs is the leader in the vaccine industry, and we have extensive experience in developing vaccines and possess mature facilities and personnel.

Feasibility of Yeast Being Used as A Vaccine Vector

Whole Inactivated Yeast Based T-Cell Vaccines

Saccharomyces cerevisiae is used as a vector for the development of vaccines against infectious diseases and cancers because of its non-toxicity. Moreover, this yeast can be killed by heat before administration, and it has been proven in many clinical trials that the so-treated yeast is safe for humans and does not reach the maximum tolerated dose. More importantly, the large expression of one or more antigens by S. cerevisiae is relatively simple and stable, and the species can be rapidly propagated and purified. In terms of immune mechanisms, the researchers also found that S. cerevisiae can induce strong immune responses against non-self antigens. These characteristics indicate that S. cerevisiae is an ideal vaccine vector. Some studies have further supported the above points, that is, recombinant S. cerevisiae expressing tumor-associated antigens can protect vaccine recipients from tumor challenges and prevent tumor formation and growth. Even in mice bearing tumors, the growth rate of tumors slowed down after inoculation of recombinant S. cerevisiae constructs.

Whole Inactivated Yeast Based T-Cell Vaccine Platform

Whole inactivated yeast based T-cell vaccine platform is a derivative from the above fundamentals. Briefly, using genetic engineering techniques, we could obtain haploid S. cerevisiae that can express heterologous antigens, which was then added to pre-heated 56 °C PBS for 1 hour to inactivate yeast. The yeast thus obtained is intact, containing the target antigen, and is non-toxic. The immunization of the thus prepared yeast constructs revealed that antigen-presenting cells (APCs) can bind to yeast by phagocytic through interactions with toll-like receptors on their surface and are activated to take up yeast, so that the heterologous antigen expressed by the yeast will then be cross-presented on the surface of the APCs. The effect of this is that the CD4+ and CD8+ T-cell responses in the body are stimulated, which in turn can play a role in killing pathogens and tumor cells. In addition, vaccines prepared by whole inactivated yeast based T-cell vaccines platform can also reduce the number of regulatory T cells and inhibit their function, and relieve their suppression of immune response. These immune mechanisms and experimental data show that the whole inactivated yeast based T-cell vaccines platform is an excellent platform for infectious disease and cancer vaccine development.

By integrating its years of experience serving vaccine researchers and building a team of leading vaccine development experts, Creative Biolabs has now successfully developed a range of platforms for the development of infectious diseases and cancer vaccines. We believe that our more than ten years of experience in vaccine development and the assistance of a professional team can help you complete your vaccine development tasks and solve the problems you have encountered in the process!


All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.


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All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.

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