Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsVesicle-associated membrane protein 8 encoded by VAMP8 gene was first identified as an endosomal SNARE. SNARE is recruited to mature autophagosomes where it forms a complex with endolysosomal VAMP8 and cytoplasmic synaptosomal-associated protein (SNAPs). SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. VAMP8 has been revealed to participate in biological functions like endosomal fusion, the exocytosis of GLUT4 and insulin, sequential granule-to-granule fusion and autophagy.
| Basic Information of VAMP8 | |
| Protein Name | Vesicle-associated membrane protein 81 Publication (VAMP-8) |
| Gene Name | VAMP8 |
| Aliases | Endobrevin (EDB) |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q9BV40 |
| Transmembrane Times | 1 |
| Length (aa) | 100 |
| Sequence | MEEASEGGGNDRVRNLQSEVEGVKNIMTQNVERILARGENLEHLRNKTEDLEATSEHFKTTSQKVARKFWWKNVKMIVLICVIVFIIILFIVLFATGAFS |
VAMP8 found in endo-lysosomes is involved in endosome-lysosome fusion or autophagosome-lysosome fusion via its interaction with the STX17-SNAP29 binary t-SNARE complex. VAMP8 is involved in dense-granule secretion. The involvement of both VAMP8 in dense-granule fusion may be related to the fact that platelet exocytosis proceeds through compound fusion between α and dense granules and the plasma membrane. VAMP8 is enriched in the membrane of pancreatic zymogen granules and is necessary for regulated secretion in response to secretagogues as well as for mis-fusion of zymogen granules with the basolateral membrane under supramaximal stimulus. VAMP8 might be a part of the machinery involved in the development of pancreatitis. VAMP8 involves the separation of the midbody during cell division, which leads to the complete separation of daughter cells. VAMP8 within other SNARE complex combinations is involved in homotypic late endosome and exocytotic fusion events.
Fig.1 SNARE-dependent fusion of platelet granules with the plasma membrane. Top panels depict α granules or dense granules (left) or lysosomes (right) in resting platelets. (Marks, 2012)
This article exemplified by VAMP8 finds the critical functions of SNAREs in tumor progression as well as chemosensitivity.
This article suggests that Sbf/MTMR13 and Rab21 GTPase activity regulates VAMP8 endosomal sorting to lysosomes in a demand-dependent fashion, serving as a novel mechanism for autophagy regulation.
This article suggests no significant association between the SNPs in VAMP8 gene region and glioma risk, indicating that these variants might not contribute to glioma susceptibility in the Chinese Han population.
This article reveals a role for VAMP8 in fusion of recycling endosomes with the plasma membrane.
This article suggests that VAMP8-/- in pancreatic acinar cells results in the enhanced expression and partial redistribution of TI-VAMP7, VAMP4, and Rab11a to ZGs and a compensatory increase in constitutive secretion.
Membrane protein studies have advanced significantly over the past few years. Based on our versatile Magic™ membrane protein production platform, we could offer a series of membrane protein preparation services for worldwide customers in reconstitution forms as well as multiple active formats. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-VAMP8 antibody development services.
During the past years, Creative Biolabs has successfully generated many functional membrane proteins for our global customers. We are happy to accelerate the development of our clients’ programs with our one-stop, custom-oriented service. For more detailed information, please feel free to contact us.
Reference
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
