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Vasoactive Intestinal Polypeptide Receptor Family

Vasoactive intestinal polypeptide receptors are class B G protein-coupled receptors (GPCRs) and are receptors for the vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP). VIPs and PACAPs are members of a superfamily of structurally related peptide hormones that mediate diverse and important physiological and biological functions. VIPs and PACAPs act via three different receptors: VIPR1, VIPR2, and PAC1. PAC1 receptors are selective for PACAP, whereas VIPR1 and VIPR2 respond to both VIP and PACAP with high affinity. These receptors have been identified in various tissues, including brain, lung, kidney, gastrointestinal tract, tongue, and also on immunocompetent cells. In the CNS, these receptors function in the control of circadian rhythms, learning and memory, anxiety and responses to stress and brain injury. In the periphery, they are involved in the control of immunity and inflammation, the control of pancreatic insulin secretion, the release of catecholamines from the adrenal medulla, and as co-transmitters in autonomic and sensory neurons.

Here, we give a separate introduction and a brief summary of part of the vasoactive intestinal polypeptide receptors focusing on our current understanding of their structure, pharmacology and functions, and their likely physiological roles in health and disease.

Human Vasoactive Intestinal Polypeptide Receptor Members
VIPR1 VIPR2

To help strengthen our knowledge about these receptors and promote future therapeutic applications, Creative Biolabs is now offering services in every step of the membrane protein preparation process, including expression, solubilization, stabilization, and purification. We now introduce our comprehensive and versatile Magic™ membrane protein production platform to help handle these difficult-to-prepare targets and facilitate the in vitro studies. We can reconstitute your proteins into various membrane mimetics, including detergent micelles, proteoliposomes, nanodiscs, lipoparticles, polymers, etc.

Magic™ membrane protein production platform – Creative Biolabs

Moreover, supported by our Magic™ membrane protein antibody discovery platform, we can further provide antibody discovery services targeting these membrane proteins. We also present DNA immunization service for anti-membrane protein antibody development. Contact us for more detailed information about our membrane protein preparation services.

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