Creative Biolabs has been long-term committed to developing virus-like particle (VLP) technology in yeast cells system. We are honored to use our advanced platforms and extensive experience to serve our valued customer with the best service and the most qualified products.
Virus-like particles (VLPs) are multiprotein structures which resemble the conformation of native viruses while lacking a viral genome, potentiating their application as cheaper and safer vaccines and immunogens. In addition, VLPs are also frequently applied in membrane protein expression, delivery systems, bioimaging and cell targeting, and many other fields.
Figure 1. Representative pictures of virus-like particles (VLPs) under electron microscopy. (BMC biotechnology, 2014)
Yeast system manifests as one commonly used cell-based machinery for production of a variety of VLPs from bacterial, yeast, plant and mammalian origin. Hansenula and Pichia strains, two most representative yeast strains, are more biologically complicated than E. coli since yeast vectors need to be propagated in bacteria first and then introduced into yeast cells. However, compared with E. coli, yeast system exhibits multiple critical advantages, such as:
Creative Biolabs has already proven that several mammalian VLPs can be successfully obtained using yeast cells. We now provide multiple yeast strains as powerful expression machinery for VLPs production, including Pichia pastoris, Hansenula polymorpha and saccharomyces cerevisiae, etc.
Creative Biolabs now offers unparalleled virus-like particle (VLPs) service based on yeast cells system. With years of nonstop exploration, our scientists have also established several other expression systems including:
We are able to provide a broad range of VLPs related services from production, optimization, characterization to functionalization strategies. As alternatives, we also provide in-house VLPs products derived from various virus families (e.g. HBV VLP, HIV VLP, HPV VLP, CA16 VLP, EV71 VLP, poliovirus VLP, polyomaviruses VLP, AAV VLP, bacteriophage Qβ VLP, Zika VLP, etc.). Please feel free to inquire us for further discussions.