Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications. Highlights
Creative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsSolution viscosity has been one of the most troublesome problems for the high-concentration formulation of protein drugs. Viscosity measurement is a method to determine the fluid viscosity and flow properties of liquids using a viscometer. As a professional supplier in the bio-manufacturing field, Creative Biolabs devotes to the manufacturability assessment of a potential drug candidate and is able to evaluate key manufacturability parameters, including liquid viscosity, via our proven CreDA™ platform. Remarkably, we provide a variety of different styles of powerful viscometers and corresponding custom services to perform a precise and repeatable viscosity determination for worldwide scientists.
When the liquid moves in a definite direction and its velocity has a gradient regarding the direction rectangular to that of flow, a force of internal friction is produced along both sides of a hypothetical plane parallel to the movement. This flow feature of the liquid is expressed in terms of a concept, viscosity. In medicine, the viscosity of drug solutions results from some types of interactions between protein molecules, as listed in Table 1. The electrostatic repulsion regulated by Coulomb’s law is a primary cause that determines the overall solution property owing to the long-range interaction. The other repulsive possibility is the exclusion volume effect by steric repulsion, very short interaction with a contact distance between atoms.
Tab.1 Major interaction depended on the distance. (Hong, 2018)
The Viscosity Measurement Services at Creative Biolabs
Viscometer, also named viscosimeter, is an instrument designed to determinate the viscosity of liquid samples. This device makes use of a theoretical relationship between shear stress and strain rate to execute assays. Viscometer using simple flows (one-dimensional, steady, fully developed) in which both shear stress and strain rate could be measured. There’re three major types of this equipment: flow, drag, and resonant.
Fig.1 Setup of the simple capillary viscometer. (Pham, 2018)
At Creative Biolabs, we possess a diversity of viscometers can be provided for clients in the viscosity/KD assays and acquire proficiency in their internal characteristics to deal with any challenging projects. Our popular viscometer types including but not limited to:
The viscosity is one of the key parameters in the manufacturability assessment. Here, our versatile CreDA™ platform creates the potential to evaluate the technical viability of a drug candidate and finally screen the most appropriate agent during drug development. Our diversiform measurement services are displayed below.
Capillary viscometers • Glass capillary • Viscometers • Orifice/cup, short capillary: saybolt viscometer
Falling sphere • Falling cylinder • Falling methods in opaque • Liquids • Rising bubble/droplet
In addition, we offer two special systems, plasma viscosity and dietary fiber viscosity, to determine solution viscosity in the clinical practice. For example, plasma is a Newtonian fluid. Its viscosity is independent of blood flow characteristics but is basically decided by water-content and macromolecular components of blood. As for dietary fibers, viscosity is a physicochemical property for them.
As a physical stability assessment, the viscosity/KD assay data can be informative for downstream processing and facilitate to select drug candidates that perform well in the preferred formulation platform. Based on advanced technology and dedicated device, Creative Biolabs has launched many different physical stability assessment services, particularly viscosity/KD determinations to precisely evaluate liquid samples. For more information, please don’t hesitate to contact us.
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All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
