VN1R1 Membrane Protein Introduction

Introduction of VN1R1

VN1R1, a G protein-coupled receptor, is encoded by VN1R1 gene. It is a receptor for pheromones which indicates it offers numerous functions on social and sexual behavior. VNIR1 is expressed in vomeronasal sensory neurons (VSNr) of the vomeronasal organ (VNO), which is a distinct structure besides the main olfactory epithelium (MOE). It is activated by volatile compounds in a heterologous system.

Basic Information of VN1R1
Protein Name Vomeronasal type-1 receptor 1
Gene Name VN1R1
Aliases V1RL1, VNR19I1
Organism Homo sapiens (Human)
UniProt ID Q9GZP7
Transmembrane Times 7
Length (aa) 353

Function of VN1R1 Membrane Protein

The VN1R1 is detected in several other tissues, including the main olfactory epithelium (MOE), brain, lung, and kidney. Some studies conducted on VN1R1 indicate that Hedione is a ligand for VNIRI expression, which suggests it may play a role in gender-specific modulation of hormonal secretion in humans. Meanwhile, recent research report VN1R1 gene can encode the olfactory receptor QR7D4. It could not only benefit future studies of human VNRs but also help identify their biological roles.

Structure of Vomeronasal receptor, type 1. Fig.1 Structure of Vomeronasal receptor, type 1.

Application of VN1R1 Membrane Protein in Literature

  1. Henningsson S., et al. A missense polymorphism in the putative pheromone receptor gene VN1R1 is associated with sociosexual behavior. Transl Psychiatry. 2017, 7(4): e1102. PubMed ID: 28440809

    Authors study the sociosexual behavior of two individuals, trying to find the relationship between VN1R1 SNP and sociosexual behavior. The data show that human social interaction is modulated by communication via chemosignals.

  2. Corin K., et al. Structure and function analyses of the purified GPCR human vomeronasal type 1 receptor 1. Sci Rep. 2011, 1: 172. PubMed ID: 22355687

    This article reports the ability to express and purify milligrams of purified, functional human vomeronasal receptor hVN1R1, which provides evidence on understanding how mammalian scent detection works.

  3. Wallrabenstein I., et al. The smelling of Hedione results in sex-differentiated human brain activity. Neuroimage. 2015, 113: 365-73. PubMed ID: 25797832

    Authors in this group analyze the expression level of VN1R1 in the human olfactory mucosa, trying to find whether Hedione is a ligand for the putative human pheromone receptor VN1R1. Results indicate that the putative human pheromone receptor VN1R1 is involved in extra-olfactory neuronal activations induced by the odorous substance Hedione.

VN1R1 Preparation Options

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