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HighlightsIntroduction of VN1R1
VN1R1, a G protein-coupled receptor, is encoded by VN1R1 gene. It is a receptor for pheromones which indicates it offers numerous functions on social and sexual behavior. VNIR1 is expressed in vomeronasal sensory neurons (VSNr) of the vomeronasal organ (VNO), which is a distinct structure besides the main olfactory epithelium (MOE). It is activated by volatile compounds in a heterologous system.
| Basic Information of VN1R1 | |
| Protein Name | Vomeronasal type-1 receptor 1 |
| Gene Name | VN1R1 |
| Aliases | V1RL1, VNR19I1 |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q9GZP7 |
| Transmembrane Times | 7 |
| Length (aa) | 353 |
| Sequence | MVGDTLKLLSPLMTRYFFLLFYSTDSSDLNENQHPLDFDEMAFGKVKSGISFLIQTGVGILGNSFLLCFYNLILFTGHKLRPTDLILSQLALANSMVLFFKGIPQTMAAFGLKYLLNDTGCKFVFYYHRVGTRVSLSTICLLNGFQAIKLNPSICRWMEIKIRSPRFIDFCCLLCWAPHVLMNASVLLLVNGPLNSKNSSAKNNYGYCSYKASKRFSSLHAVLYFSPDFMSLGFMVWASGSMVFFLYRHKQQVQHNHSNRLSCRPSQEARATHTIMVLVSSFFVFYSVHSFLTIWTTVVANPGQWIVTNSVLVASCFPARSPFVLIMSDTHISQFCFACRTRKTLFPNLVVMP |
Function of VN1R1 Membrane Protein
The VN1R1 is detected in several other tissues, including the main olfactory epithelium (MOE), brain, lung, and kidney. Some studies conducted on VN1R1 indicate that Hedione is a ligand for VNIRI expression, which suggests it may play a role in gender-specific modulation of hormonal secretion in humans. Meanwhile, recent research report VN1R1 gene can encode the olfactory receptor QR7D4. It could not only benefit future studies of human VNRs but also help identify their biological roles.
Fig.1 Structure of Vomeronasal receptor, type 1.
Application of VN1R1 Membrane Protein in Literature
Authors study the sociosexual behavior of two individuals, trying to find the relationship between VN1R1 SNP and sociosexual behavior. The data show that human social interaction is modulated by communication via chemosignals.
This article reports the ability to express and purify milligrams of purified, functional human vomeronasal receptor hVN1R1, which provides evidence on understanding how mammalian scent detection works.
Authors in this group analyze the expression level of VN1R1 in the human olfactory mucosa, trying to find whether Hedione is a ligand for the putative human pheromone receptor VN1R1. Results indicate that the putative human pheromone receptor VN1R1 is involved in extra-olfactory neuronal activations induced by the odorous substance Hedione.
VN1R1 Preparation Options
To obtain the soluble and functional target protein, the versatile Magic™ membrane protein production platform in Creative Biolabs enables many flexible options, from which you can always find a better match for your particular project. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-VN1R1 antibody development services.
As a forward-looking research institute as well as a leading custom service provider in the field of membrane protein, Creative Biolabs has won good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including generation of many functional membrane proteins. Please feel free to contact us for more information.
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