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HighlightsPalmitoyltransferase ZDHHC17 is encoded by the ZDHHC17 gene. ZDHHC17 has two distinct features compared with other DHHCs, it has seven cytoplasmic ankyrin repeats at the N terminus and six predicted transmembrane helices instead of four. DHHC17 is localized to the Golgi membrane, and in humans, it is highly expressed in the brain. DHHC17 has been shown to recruit via its seven-AR domain. It palmitoylates many synaptic proteins, including cysteine string protein (CSP), GluA1, GluA2, PSD95, synaptosomal-associated protein 25 (SNAP25), synaptotagmin 1 (SYT1), the HD disease-causing protein huntingtin (HTT).
| Basic Information of ZDHHC17 | |
| Protein Name | Palmitoyltransferase ZDHHC17 |
| Gene Name | ZDHHC17, HIP14, HSPC294 |
| Aliases | Huntingtin yeast partner H, Huntingtin-interacting protein 14 (HIP-14), Huntingtin-interacting protein 3 (HIP-3), Huntingtin-interacting protein H, Putative MAPK-activating protein PM11, Putative NF-kappa-B-activating protein 205, Zinc finger DHHC domain-containing protein 17 (DHHC-17) |
| Organism | Homo sapiens (Human) |
| UniProt ID | Q8IUH5 |
| Transmembrane Times | 6 |
| Length (aa) | 632 |
| Sequence | MQREEGFNTKMADGPDEYDTEAGCVPLLHPEEIKPQSHYNHGYGEPLGRKTHIDDYSTWDIVKATQYGIYERCRELVEAGYDVRQPDKENVTLLHWAAINNRIDLVKYYISKGAIVDQLGGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVDMMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVISLLLEAGANVDAQNIKGESALDLAKQRKNVWMINHLQEARQAKGYDNPSFLRKLKADKEFRQKVMLGTPFLVIWLVGFIADLNIDSWLIKGLMYGGVWATVQFLSKSFFDHSMHSALPLGIYLATKFWMYVTWFFWFWNDLNFLFIHLPFLANSVALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSLDLSIFCSTCLIRKPVRSKHCGVCNRCIAKFDHHCPWVGNCVGAGNHRYFMGYLFFLLFMICWMIYGCISYWGLHCETTYTKDGFWTYITQIATCSPWMFWMFLNSVFHFMWVAVLLMCQMYQISCLGITTNERMNARRYKHFKVTTTSIESPFNHGCVRNIIDFFEFRCCGLFRPVIVDWTRQYTIEYDQISGSGYQLV |
ZDHHC17 was recently identified as a key player in ischemic stroke and a regulator of neuronal cell death. In addition to its well-studied function in protein palmitoylation, other roles of ZDHHC17 need to be identified clearly, including the mediation of Mg2+ transport, regulation of Ca2+ channel functions and activation of c-Jun N-terminus kinase (JNK) pathways. Moreover, ZDHHC17 is responsible for palmitoylation of large-conductance calcium- and voltage-activated potassium (BK) channels, which control membrane potential and calcium influx. ZDHHC17 may be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. However, the roles and molecular mechanisms of ZDHHC17 in neuronal development and function are not yet fully understood.
Fig.1 DHHC PAT domain structure and membrane topology. (Sanders, 2015)
This article finds that ZDHHC17 is a neuron-intrinsic factor for axon growth that is crucial for TrkA-tubulin interaction, which regulates signal transmission, including ERK1/2 phosphorylation.
This article identifies variations of a novel unstructured peptide motif in many proteins, which is specifically required for binding to the AR domains of zDHHC17 and zDHHC13.
This article suggests that none of the other DHHC PATs are compensating for the loss of Hip14 and Hip14l by up-regulation of expression at the mRNA level.
This article reveals that HIP14 is essential for the maintenance of life and neuronal integrity in the adult mouse.
This article suggests the involvement of multiple candidate HIP14 substrates and regulators in HD, highlighting the significance of palmitoylation by HIP14 is a key contributor to the pathogenesis of the disease.
Membrane protein studies have advanced significantly over the past few years. Based on our versatile Magic™ membrane protein production platform, we could offer a series of membrane protein preparation services for worldwide customers in reconstitution forms as well as multiple active formats. Aided by our versatile Magic™ anti-membrane protein antibody discovery platform, we also provide customized anti-ZDHHC17 antibody development services.
During the past years, Creative Biolabs has successfully generated many functional membrane proteins for our global customers. We are happy to accelerate the development of our clients’ programs with our one-stop, custom-oriented service. For more detailed information, please feel free to contact us.
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