02Dec/23

Scientists identify a special gene that produces key antibodies in large quantities

December 2, 2023Biological KnowledgeHybridoma Sequencing, IgG, single B cellsbiolabs

Antibodies are a class of proteins that are important to the body’s immune system. Immunoglobulin G (IgG) stores memories of past infections and marks dangerous microbes so they can be destroyed byRead More…

31Oct/23

The molecular mechanism by which special antibodies protect the body against HIV infection

October 31, 2023Immunotherapy Researchantibody development, HIV-1, neutralizing antibodiesbiolabs

Neutralizing antibodies targeting HIV-1 Env have now been shown to protect against systemic infection. Recently, scientists from the University of Bochum in Germany and other institutions have discovered through research that HIVRead More…

07Oct/23

Multispecific antibodies enhance cancer immunotherapy

October 7, 2023Antibody Engineering Research, Biological Knowledge, Drug Discovery Researchimmunotherapy, monoclonal antibody, multi-specific antibodiesbiolabs

Immunotherapy shines in tumor treatment. In 2021, more than 100 monoclonal antibody drugs have been approved. In addition to monospecific antibodies, the development of multispecific antibodies is also in full swing. AtRead More…

27Aug/23

Scientists have cracked HIV’s new way of entering the host cell nucleus, which may lead to new therapeutic drugs

August 27, 2023Drug Discovery ResearchHIV-1, Protein Protein Interactionbiolabs

Human immunodeficiency virus 1 (HIV-1) is a retrovirus, and most HIV-1 infections occur on the mucosal surface of the human reproductive tract. After HIV-1 enters the nucleus of the host cell, itRead More…

31Jul/23

Antibody sequencing provides a new path for antibody therapy research

July 31, 2023Biological KnowledgeAntibody Discovery, antibody sequencing, Hybridoma, phage display, Single B cell technologybiolabs

Therapeutic Antibody Drugs Since the first clinical application approval in 1986, more than 100 therapeutic antibody drugs have entered clinical application successively, and new antibody drugs are in the process of developmentRead More…

29Jun/23

Monoclonal Antibodies: How to Choose an IgG Subtype

June 29, 2023Biological Knowledgeadcc, IgG, Therapeutic Antibodybiolabs

Introduction to antibody structure and function An antibody molecule composes of an antigen-binding fragment (Fab) and a crystallizable fragment (Fc), forming a Y-shaped structure. The Fab region is a mixed light andRead More…

29Jun/23

Application of Single Domain Antibodies in Cell Therapy

June 29, 2023Drug Discovery ResearchAntibody Discovery, gpcr, Therapeutic Antibodybiolabs

G protein-coupled receptor (GPCR) is a very important receptor protein on the cell surface. In the human genome, GPCR-encoding genes account for more than 2% and contain more than 800 members, makingRead More…

01Jun/23

The road to lead antibody generation—hybridomas, antibody libraries, and single B cells

June 1, 2023Biological Knowledgeantibody production, B-cell sorting, Hybridoma, phage dispaly, Therapeutic Antibodybiolabs

Currently, the more common technical routes for lead antibody production mainly include hybridoma, antibody library, and single B cells. Among them, hybridoma technology and antibody library technology were applied earlier, and singleRead More…

14Apr/23

Introduction to Antibody-Drug Conjugates

April 14, 2023Biological KnowledgeAntibody Drug Conjugation, monoclonal antibody, Therapeutic Antibodybiolabs

Basic Structure of ADCs Antibody-drug conjugates (ADCs) are conjugates consisting of three basic components: monoclonal antibodies (which target specific tumor antigens), highly potent cytotoxic small molecule payloads, and linkers. The basic structureRead More…

27Mar/23

Selection of Protein Expression System

March 27, 2023Biological Knowledgemembrane protein, protein expression system, protein synthesisbiolabs

The protein expression system is similar to a sophisticated instrument that continuously delivers proteins to the outside world. The central law is the simplest one which is that the terminal is theRead More…