Merkel cell carcinoma (MCC) is an aggressive neuroendocrine cutaneous cancer with a high incidence and mortality, especially in older patients. Traditional therapeutic strategies such as surgery and radiotherapy are primary therapies currently resulting in locoregional control to some degree. However, high failure rates highlight the need for new effective therapeutic options. Antibody-drug conjugates (ADCs) represent a promising and potential method for the treatment of recurrent MCC.
With years’ experience in the field of antibody development and bio-conjugation, Creative Biolabs is committed to offering innovative products and services to support the global drug discovery and development. At present, we provide outstanding ADCs design and construction services targeting a variety of diseases such as the Merkel-cell carcinoma. Our services range from antibody production to conjugates characterization, with comprehensive bio-conjugation and analysis platforms.
Merkel-cell carcinoma (MCC) is a rare and aggressive cancer arising from skin. Most of the cancer cases are caused by the Merkel cell polyomavirus (MCPyV or MCV) and often occur in order people. The symptoms of MCC include a fast-growing tumor, painless nodule (tumor) on skin. MCC also appears on the face, head or neck and other areas. The research found that the main cause of cancer is the Merkel cell polyomavirus, but other risk factors still play a critical role in the development of this cancer. Risk factors commonly include excessive exposure to sunlight, a weakened immune system, having a history of other skin cancers, older age and light skin color. So far, the treatment approaches for MCC generally include surgery, radiation therapy, immunotherapy and chemotherapy.
Fig.1 Graphic summary of the 4 putative cells of origin of Merkel cell carcinoma (MCC). (Kervarrec, 2019)
Fig.2 Lorvotuzumab mertansine (LM) mechanism of action. (Berdeja, 2014)
At Creative Biolabs, we are committed to providing world-class ADCs development services targeting cancers such as the MCC. Our scientist team is able to promptly and effectively design and create optimal ADCs products for your drug discovery project. Please contact us for more information if you are interested in our services.
References
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