IVD Antibody & Immunoassay Development Services for AMH Marker

As a world-leading services provider of application-specific antibody development, Creative Biolabs introduces our in vitro diagnostic (IVD) antibody development and immunoassay development services for the anti-Müllerian hormone (AMH) marker to improve the diagnosis of ovarian diseases such as polycystic ovary syndrome (PCOS) and granulosa cell tumor (GCT).

Introduction to AMH Marker

AMH is a homodimeric glycoprotein that belongs to the transforming growth factor β (TGF-β) family. The 5-exon, 2.75-kb AMH gene is located on human chromosome 19p13.3 and encodes a 560-amino-acid glycoprotein that forms a 140-kD homodimer. AMH is first known for its role during sexual differentiation. The secretion of AMH by the embryonic testes can inhibit the growth of the Müllerian (female) ducts in the embryogenesis while testosterone produced by the testes causes the Wolffian ducts, which are responsible for male reproductive parts, to survive. AMH is also known for its role in ovarian function and regulating sex steroid production. Studies have reported the applications of AMH is the clinical field, including:

• Used to assess ovarian reserve and the capacity to provide eggs for fertilization.
• Used for prediction of response to controlled ovarian stimulation.
• Used for evaluation of sexual ambiguity and to distinguish between hypogonadism and delayed puberty.
• Used in the diagnosis and management of patients with a GCT.
• Used as diagnostic tools for PCOS.

Fig.1 AMH in the induction of Müllerian regression during male embryogenesis. (Quigley, 2006)

Development of Immunoassays for AMH Measurement

As AMH has been identified as a marker of different ovarian disorders, diagnostic immunoassays can be developed for AMH measurement to aid in the clinical diagnosis of these diseases. Reported immunoassays have used antibody pairs directed to different epitopes of AMH to measure the level of AMH with relatively high specificity and sensitivity. At Creative Biolabs, we have established a comprehensive IVD platform to offer unparalleled custom-specific IVD antibody development services clients with IVD requirements. We also offer one-stop immunoassay development services for AMH marker, providing antibody development, antibody conjugation, assay design, protocol establishment, optimization, and kit production services. For more information, please click the links below:

• IVD Antibody Development
• Antibody Pair Development
• Antibody & Protein Conjugation
• IVD Immunoassay Development

Features of Our Services

• Flexibility in antibody/immunoassay development services to suit the specific needs of the clients
• Abundant expertise with know-how in all steps of the research, development, manufacture, and assembly process.
• Quick response and expert technical support from inquiry to project completion
• Cutting-edge technologies, in-depth expertise, and reasonable prices

Creative Biolabs has successfully completed numerous IVD antibody generation and development projects for clients across the globe. We are confident that our commitment to science and research will enable us to offer you the best products and services. Please feel free to contact us for more information and a formal quote.

References

1. Quigley, C. A., (2006). “Genetic basis of gonadal and genital development.” DeGroot LJ, Jameson JL. Endocrinology. 5th ed. Philadelphia: Elsevier Saunders.
2. Victoria, M., (2018). “Anti Müllerian Hormone: more than a biomarker of female reproductive function.” Journal of Gynecology Obstetrics and Human Reproduction.

For Research Use Only.