A very interesting additional family of analytes serving as biomarkers in blood samples are metabolites, including immune modulating amino acids, (anti)-oxidants, and members of different lipid classes. Metabolite biomarkers have demonstrated the potential in precision diagnostics. Creative Biolabs is a well-recognized leader in the field of in vitro diagnostics (IVD). We proudly introduce our professional metabolite detection services with our advanced analytical platforms.
Metabolomic experiments typically use analytical platforms such as gas chromatography-mass spectrometry (GC-MS), liquid-chromatography mass spectrometry (LC-MS), capillary electrophoresis mass spectrometry (CE-MS), and nuclear magnetic resonance (NMR) to analyze and quantify metabolites in a sample. These metabolomic experiments could be targeted to a specific metabolite, a class of metabolites, or all metabolites in an unbiased manner. Targeted analyses focus on up to a hundred metabolites, while untargeted approaches can cover hundreds or even thousands in a single experiment. Targeted approaches are empowered by known changes in cancer metabolism. In some cases, it may associate cancer-specific genetic alterations to changes in metabolite concentration and design a strategy to discriminate between different types of cancer.
Measurement of metabolite markers can offer insight into disease progression in both primary tumor and metastatic compartments, and can also be used as a means of screening for and diagnosing early-stage cancers. Equipped with industry-leading expertise and state-of-the-art equipment, Creative Biolabs is fully competent and dedicated to serving as your one-stop-shop for liquid biopsies. We offer comprehensive analysis services for liquid biopsies, including circulating tumor cells (CTCs), cell-free tumor DNA (ctDNA), cell-free tumor RNA (ctRNA), exosome, tumor-educated platelets, protein detection, metabolites, and nucleosome. Advancements in instruments are adequate to allow the identification of metabolite biomarkers. However, the field is still hindered by different analytical challenges.
With years of experience in the identification of metabolite biomarkers, Creative Biolabs has perfected our technical pipelines for metabolite detection. Experimental procedures and materials, as well as data handling and statistical analyses, have been standardized to ensure analytical validation of metabolite biomarkers. We would like to share our cutting technologies for metabolite detection to facilitate our customers' research and project development.
For more detailed information, please feel free to contact us or directly send us an inquiry.
Reference
For Research Use Only.
