Creative Biolabs offers focused/diverse antifungal compound libraries. Utilizing broad organic and parallel synthesis technologies (e.g. high throughput, low-volume parallel synthesis, and medium- and high-volume synthesis), Creative Biolabs has the ability to design and synthesize high-quality biologically active compounds required for different purposes. We offer our clients with the most suitable synthesis method in terms of cost, time, and scalability.
A compound library is a collection of the compound used in high throughput screening or industrial manufacturing. Each compound has its associated information, such as the chemical structure, purity, quantity, and physiochemical characteristics. The stored compound libraries should have a fully represented or sampled chemical space to prevent molecular interactions.
Compound libraries are useful tools for drug discovery. We provide several types of antifungal compound libraries, including natural product library, target-specific libraries (such as polyenes, azoles, and echinocandins) and FDA-approved antifungal drug library. Our ready-to-use compound libraries consist of over 3000 molecules, and their biological and pharmacological activities are fully validated. These libraries are available for high throughput screening (HTS), fragment-based screening, and high content screening (HCS).
Natural Product Library
Recent studies showed that two out of the three major classes of currently used antifungals, like polyene and echinocandins, are derived from natural products. Antifungal drug selection still pays attention to natural products which represent the most exquisite examples of therapies - selecting for their activities through evolution. In Creative Biolabs, we keep efforts on natural product library. Our library is composed of 800 pure natural compounds as leads identifying materials. The sources and reference information (e.g. chemical structure, purity, quantity, and physiochemical characteristics) of our natural samples are available. This extensive diversity library stays great value for antifungal drug selections that apply to various targets.
Target-Specific Libraries
Until now, the therapeutic options for invasive fungal infections are quite limited and include only three main classes of drugs: polyenes, azoles, and echinocandins. Polyenes are the oldest class of antifungal drugs. This class of antifungal drugs, such as amphotericin B, binds to ergosterol, a membrane sterol that is unique to fungi, to treat systemic infections. The most abundant antifungal class identified in natural product library is echinocandins, which inhibits the synthesis of 1,3-β-glucan, a key component of the fungal cell wall. Azoles are the most abundant class when screening synthetic chemical libraries, which inhibit ergosterol biosynthesis. Other antifungal libraries are also included, for example allylamines and morpholines, which inhibit ergosterol biosynthesis; flucytosine and griseofulvin, which inhibit nucleic acid biosynthesis and mitosis.
FDA-Approved Antifungal Drug Library
FDA-approved products are more safety and effectiveness. These products have already confirmed by literature, patent reports, and clinical research. We offer up-to-date medical molecules and access to our antifungal drug libraries.
Creative Biolabs dedicates to discovering innovative antifungal drugs that using superior methodologies and technologies to address the chemical libraries, targets, and pathways. For more detailed information, please feel free to contact us or directly sent us an inquiry.
Reference
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