Creative Biolabs is capable of providing the most reliable and comprehensive choroidal neovascularization model creation service for global clients. We have developed the most advanced Micron IV platform guided by real-time fundus imaging to ensure the CNV model creation a success. Our professional scientists will help you fully investigate the mechanism of wet age-related macular degeneration.

What Is Choroidal Neovascularization Model?

Wet age-related macular degeneration (AMD) is a major cause of blindness and vision impairment in the elderly. But the mechanism of AMD is still unknown. Therefore, choroidal neovascularization model is created by mimicking the condition of wet age-related macular degeneration (AMD) to accelerate the preclinical development. Moreover, CNV model has been widely used to predict the clinical efficacy of anti-vascular endothelial growth factor (VEGF) therapy for neovascular AMD, which include treatments with drugs, recombinant proteins, antibodies, adenoviruses, and pre-microRNAs.

Our Capabilities

As a leading company in the industry, Creative Biolabs is able to partner with you at any stage of the model design to accelerate project timelines in your area of application. Importantly, our experienced experts can provide professional advice on numerous parameters that might influence the outcomes into consideration, which include animal strain, age, laser settings, and location of lesions. In addition, we have developed a series of non-invasively perform fluorescein angiography imaging system to assess the vascular leakage between control and treated eyes:

  • Fluorescein angiography (FA)
  • Micron IV imaging system
  • Indocyanine green (ICG) angiography
  • Spectral domain optical coherence tomography (OCT)

To fully assess the efficacy of new drugs, our experts will conduct a series of postmortem evaluations, which include as following:

  • Immunohistochemical on ocular sections
  • PCR on ocular tissues to evaluate up/down gene regulation
  • Ocular tissue distribution
  • Histopathology
  • Electroretinograms
  • Visualization and quantification of size of the lesion

Creative Biolabs also offers other related rodent ocular disease models for global clients. Our one-stop service is more than managing the project. No matter how simple or complex your requirements are, our experienced scientists will satisfy you with the best service that meets your requirements.

Creative Biolabs is committed to be your trusted and reliable research service provider and strive to help you with our incomparable technology. We can also provide customized service in order to meet specific requirements of our customers. Please feel free to contact us, and we'll get in touch with you within 24h.

For Research Use Only.



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