Surfaced Arrayed Therapeutics Technology

Creative Biolabs is a world leader in the field of vaccine adjuvants development and the platforms of delivery system. With our extensive experience and advanced platform, we are therefore confident in offering the best services for the delivery system for use in vaccine development and guarantee the finest results for our customers all over the world.

Surfaced Arrayed Therapeutics Technology

Vaccines are the preparations given to patients to evoke immune responses leading to the production of antibodies (humoral) or cell-mediated responses that will combat infectious agents or noninfectious conditions such as malignancies. It is necessary to develop a new technology of prophylactic and therapeutic vaccines to promote effective immunization due to the poor patient compliance with the weak immunogenicity of subunit vaccines to booster doses which should potentiate prime doses are few strong reasons. A lot of efforts are being made to deliver vaccines through carriers as they control the spatial and temporal presentation of antigens to immune system thus leading to their sustained release and targeting. The surfaced arrayed therapeutics technology (SAT) is a disruptive nanoparticle platform that gives new options for improving the potency, safety, and utility of both large and small molecule therapeutics. The SAT is a modern drug delivery technology which can be used in applications ranging from oncology to vaccines. It possesses the specificity of antibody and the versatility of nanoparticle and covers several structures that combine nanoparticles with modified surface bound large molecules. The SAT services offer is a highly versatile and rapidly deployed solution that does not require covalent modifications of targeting molecules and biopharmaceuticals. The technology is very useful for both therapeutics and vaccines.

Attributes of SAT

Particle size is an important consideration while formulating microparticulate systems as it influences their uptake and release and hence immune responses. Small (<10 μm) microspheres due to their large surface to mass ratio, are capable of facilitating extracellular delivery of antigen to the phagocytic accessor cells leading to faster release and increased antigen processing. Larger particles could not be phagocytosed by macrophages until they have disintegrated into smaller debris. A combination of larger and smaller particles might produce a pulsatile pattern for antigen release thus mimicking an immunization process involving prime and booster shots. For the hydrophobic drug loading, the solid-lipid particles of SAT are suitable for broad portfolio of drugs. It composed of waxes, lipids, and surfactants and has successfully applied for over 500 drugs. It has high drug loading potential on account of a molar ratio that is greater than 100 for drug to antibody in particles and is also applicable to other particle types such as liposomes. The SAT was used successfully in the improved delivery of drugs to tumors and other diseases. For the particle targeting, surface of SAT can be customized to bind drugs, biological ligands, and biopharmaceuticals, including antigen specific antibodies. Particle surface modified with safe and standard cationic, anionic and neutral surfactants.

A Flexible Platform of SAT

SAT is a flexible platform with the features as follows. All of these make the SAT has a widely application in delivery for both therapeutics and vaccines.

• accommodate a broad array of drugs and biopharmaceuticals individually and in combinations;
• completely tunable ratio of combined components;
• non-covalent linking biological ligands with other drugs;
• extracellular and intracellular delivery;
• sustained release of drugs and biopharmaceuticals;
• multi-functional formulations including multiple antibody specificities for cross-linking target antigens;
• links vaccine antigens to immunomodulators, like TLR agonists;
• used for both mucosal and parenteral administration.

Creative Biolabs is a leader in the field of vaccine adjuvant development and has focused on the platform of surfaced arrayed therapeutics technology for many years. We have experts who are able to help you with the development of the SAT for use in vaccine delivery. If you are interested in our services, please contact us for more details.

All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.