Introduction Targeted Protein Degradation (TPD) has become a revolutionary way to work for the treatment of many diseases, yet they have been very successful in the treatment of diseases that have beenRead More…
24Jan/25
13Dec/24
Latest Advances and Four Key Innovations in Targeted Protein Degradation
In the relentless pursuit of modern medicine, Targeted Protein Degradation (TPD) has emerged as a revolutionary therapeutic strategy, offering new hope for the treatment of numerous diseases. Traditional small-molecule inhibitors mainly actRead More…
05Nov/24
Innovative Approaches to Targeted Protein Degradation for Drug Development
Introduction Proteolysis-targeting chimeras are a new class of small molecules that provide alternative ways to discover drugs by leading target proteins to be selectively destroyed. In contrast to conventional inhibitors that only suppressRead More…
12Sep/24
Harnessing PhosTACs for Targeted Protein Dephosphorylation: A New Frontier in Therapeutics
Chen, Po-Han, et al. “Modulation of phosphoprotein activity by phosphorylation targeting chimeras (PhosTACs).” ACS chemical biology 16.12 (2021): 2808-2815. In the rapidly evolving field of drug development, targeting protein post-translational modifications (PTMs) has emergedRead More…
24Aug/24
Protein-degraders: The New Go-to For Tackling Autoimmune Issues
Protein targeted degradation chimera is an emerging protein degradation strategy that has been booming in recent years. It was first proposed by Craig Crews et al. in 2001. Its basic principle isRead More…
23Jul/24
Can Protein Degrader Therapy Be a Hope for AIDS Patients?
Nef is an accessory protein encoded by HIV-1, HIV-2, and other primate lentiviruses and is closely related to viral replication, persistent infection, and the development of AIDS. Nef interacts with a varietyRead More…
21Jun/24
Exploring the Impact of E3 Ligase Choice on Protein Degrader Effectiveness
The field of drug discovery is witnessing a revolutionary shift with the advent of Proteolysis Targeting Chimeras (Protein Degraders). This innovative therapeutic strategy is redefining how we approach the degradation of proteins,Read More…
14May/24
Linker Matters in Protein Degrader Design
Proteolysis targeting chimera (Protein Degrader) technology represents a breakthrough development in the field of drug discovery, utilizing the ubiquitin proteasome system to specifically degrade disease-related proteins. Protein Degraders are characterized by theirRead More…
21Apr/24
New Role Introduced: PDF-Bin, Protein Targeting the Degradation “Dumpcart”
Over the past two decades, protein-targeting degradation technologies (TPD), epitomized by Protein Degrader (proteolysis targeting chimera), have undergone rapid development and are considered one of the most promising breakthrough technologies for tacklingRead More…
18Mar/24
Extracellular Protein Targeted Degradation (eTPD): Six Drug Discovery Modalities
Targeted protein degradation (TPD) has emerged over the past decade as a major novel drug modality for the removal of intracellular proteins with bispecific small molecules that recruit proteins of interest (POIs)Read More…