In Alzheimer’s disease, fibrous tau pathology accumulates and spreads in the brain, leading to synaptic loss. Researchers studying mouse models have found that tau protein can spread from presynaptic to postsynaptic synapses,Read More…
Proteins with short lifespans control gene expression in cells and perform many crucial tasks, from aiding in brain connectivity to assisting the body in immune defense. These proteins are produced in theRead More…
In a new study, researchers from the University of Oxford, the University of Cambridge, and the Pirbright Institute in the UK have discovered a novel therapeutic approach to investigating how poxviruses evadeRead More…
The ubiquitin-proteasome system is one of the main pathways for cellular protein degradation. In recent years, methods for artificially degrading target proteins through UPS have been developed. Targeted protein degradation agents areRead More…
Introduction Various types of delivery systems, including organic/inorganic nanoparticles, small molecule targeting moieties, and antibodies, have been explored as carriers for Protein Degraders. These systems play a crucial role in addressing theRead More…
Preclinical evidence of Protein Degrader The breakthrough in Protein Degrader’s design paves the way for its early clinical trials. According to statistics, as of January 8, 2023, 18 kinds of Protein DegraderRead More…
Protein Degrader uses the natural mechanism of protein degradation in cells, that is, the ubiquitin-protease system, to induce targeted protein degradation. Compared with traditional small molecular inhibitors used in cancer therapy, ProteinRead More…
Recently, the Li Zigang and Yin Feng research group of Shenzhen Graduate School of Peking University published a research paper entitled “Targeted biomolecule regulation platform: a Split-and-Mix Protein Degrader approach” in JournalRead More…
Enzyme-Catalyzed Responsive Pro-Protein Degrader The researchers concentrated on the distinction between the tumor microenvironment and the normal cell environment and incorporated the endogenous enzyme response chemistry of tumor cell characteristics into theRead More…
Chemical protein degradation methods like protein degradation targeted chimera (Protein Degrader) allow for the simultaneous targeting of E3 ligase and disease-related proteins, with the latter then being degraded by the body’s ownRead More…