FZD1

Frizzled class receptor 1(FZD1) is a protein encoded by the FZD1 gene. It consists of a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, as well as a C-terminal PDZ domain-binding motif. Previously, it has been proven that FZD1 upregulates MDR1/P-gp expression via activating the Wnt/β-catenin pathway in neuroblastoma and breast cancer cells, however, whether FZD1 and MDR1/P-gp are related in AML is unknown.
The Wnt/β-catenin signaling pathway serves an essential role in the self-renewal and proliferation of leukemic cells. As soon as a Wnt ligand is released, it binds on the cell surface to the FZD receptor, and to low-density lipoprotein receptor-related proteins. This leads to the accumulation of non-phosphorylated β-catenin within the cytoplasm, which then migrates into the nucleus. Importantly, the activation of the Wnt signaling pathway and the overexpression of FZDs have been identified in a number of cancer tissues and cells leading to cell growth, invasion, metastasis and chemoresistance. What's more, the overexpression of FZDs such as FZD3, FZD6, or FZD9, is related to proliferation and survival in B-cell progenitor acute lymphoblastic leukemia or chronic lymphocytic leukemia and in both myelodysplastic syndromes (MDS) and acute leukemia.
Gene ID: 8321
UniProt ID: Q9UP38