In the past 20 years, Protein Degrader has ushered in a period of rapid development, especially since the successful degradation of BET protein by dBET1 Protein Degrader with pomalidomide as the ligandRead More…
14Sep/22
31Jul/22
Cell: Novel Protein Degrader—Can Be Used as A New Antibacterial Agent
Induced degradation of target proteins is a new concept in drug discovery. For eukaryotes, the ubiquitin-proteasome system is the main pathway of intracellular protein degradation, which participates in more than 80% ofRead More…
27Jun/22
Newly Discovered: The First Microbial-Derived Protein Degrader Molecule
Protein Degrader (Proteolysis-Targeting Chimera) technology, by linking E3 ubiquitin ligase to the target protein, leads to the ubiquitin modification of the target protein, which is broken down into peptides and amino acidsRead More…
19May/22
Study of Protein Degrader in Tumor Targeted Therapy-Ⅱ
Targeting tumor cell apoptosis and angiogenesis Apoptosis (or programmed cell death) is an evolutionarily conservative process that maintains tissue homeostasis under cellular stress, DNA damage and immune surveillance. However, cancer cells canRead More…
19May/22
Study of Protein Degrader in Tumor Targeted Therapy-Ⅰ
The occurrence and development of cancer is a complex process, which is characterized by continuous proliferation signals, avoidance of growth inhibitors, resistance to cell death, induction of angiogenesis, activation of invasion andRead More…
22Apr/22
Review of Protein Degrader Targeted Degradation of Protein Kinases
Protein Degrader consists of a flexible linker conjugating the protein of interest (POI) ligand and an E3 ligase ligand. Its action mechanism makes use of the mechanism of protein degradation induced byRead More…
11Apr/22
E3 Ligase, Critical for Protein Degrader Design
A core factor of Protein Degrader molecules is that protein degradants can be designed rationally by selecting ligase molecules and linkers according to the target. The module that binds to E3 ligaseRead More…
28Feb/22
Protein Degraders-Induced Protein Degradation ─ A New Model in Drug Discovery
Protein Degrader Concept Protein Degraders has become a new model of drug discovery, with the potential to change traditional drug discovery, and may become a new blockbuster therapy. Protein Degraders is aRead More…
28Feb/22
Nature: Development Directions of Protein Degrader Targeted Protein Degradation Technology in the Next 20 Years
It took nearly 20 years for Protein Degrader technology to transform from academia to preclinical and clinical drug development projects. In 2019, Protein Degrader obtained the clinical proof of concept in oncologyRead More…
20Jan/22
Cell: More han 100 Potential Protein Degrader Targets Revealed
There are about 514 different protein kinases operating in human cells, accounting for 2.5% of the entire human genome. For scientists who want to use targeted protein degradation (TPD) technology to destroyRead More…