Protein Degrader consists of a flexible linker conjugating the protein of interest (POI) ligand and an E3 ligase ligand. Its action mechanism makes use of the mechanism of protein degradation induced byRead More…
22Apr/22
11Apr/22
E3 Ligase, Critical for Protein Degrader Design
A core factor of Protein Degrader molecules is that protein degradants can be designed rationally by selecting ligase molecules and linkers according to the target. The module that binds to E3 ligaseRead More…
28Feb/22
Protein Degraders-Induced Protein Degradation ─ A New Model in Drug Discovery
Protein Degrader Concept Protein Degraders has become a new model of drug discovery, with the potential to change traditional drug discovery, and may become a new blockbuster therapy. Protein Degraders is aRead More…
28Feb/22
Nature: Development Directions of Protein Degrader Targeted Protein Degradation Technology in the Next 20 Years
It took nearly 20 years for Protein Degrader technology to transform from academia to preclinical and clinical drug development projects. In 2019, Protein Degrader obtained the clinical proof of concept in oncologyRead More…
20Jan/22
Cell: More han 100 Potential Protein Degrader Targets Revealed
There are about 514 different protein kinases operating in human cells, accounting for 2.5% of the entire human genome. For scientists who want to use targeted protein degradation (TPD) technology to destroyRead More…
23Dec/21
Protein Degrader Therapy R&D: Obstacles and Solutions
The wide range of application and the great potential in overcoming drug resistance and targeting non-proprietary targets, research and development in Protein Degrader field has been hot in recent years. Protein Degrader,Read More…
16Nov/21
Protein Degrader “modified” molecular glue—MDM2 degrader can degrade p53
Protein Degraders, also named as Proteolysis-Targeting Chimeras, is a new type of drug that is different from antibodies and traditional small molecular inhibitors. It consists of target proteins ligand, linker, and E3Read More…
21Oct/21
Blockbuster: 1336 Protein Degrader targets revealed in Nature
Protein Degrader, proteolysis targeting chimera, or proteolytic targeted chimera, is a new type of drug different from antibodies and traditional small molecule inhibitors. Protein Degrader consists of target protein binder, linker, andRead More…
14Sep/21
A strategic partnership worthy of 2.45 billion dollars reached between Pfizer and Arvinas to develop Protein Degrader protein degradants against ER+ breast cancer!
Recently, Pfizer and Arvinas announced a partnership to develop and commercialize ARV-471, an oral Protein Degrader estrogen receptor protein degrader under development. Estrogen receptor (ER) is a well-known disease driver in mostRead More…
23Aug/21
Industrial Research Report of Protein Degrader-II
Main steps of Protein Degrader to achieve intracellular protein degradation To achieve intracellular protein degradation requires multiple steps, such as cellular uptake, effective recruitment of E3 ligase, ubiquitination of target proteins, andRead More…