Protein Degrader (Proteolysis-Targeting Chimera) technology, by linking E3 ubiquitin ligase to the target protein, leads to the ubiquitin modification of the target protein, which is broken down into peptides and amino acidsRead More…
Targeting tumor cell apoptosis and angiogenesis Apoptosis (or programmed cell death) is an evolutionarily conservative process that maintains tissue homeostasis under cellular stress, DNA damage and immune surveillance. However, cancer cells canRead More…
The occurrence and development of cancer is a complex process, which is characterized by continuous proliferation signals, avoidance of growth inhibitors, resistance to cell death, induction of angiogenesis, activation of invasion andRead More…
Protein Degrader consists of a flexible linker conjugating the protein of interest (POI) ligand and an E3 ligase ligand. Its action mechanism makes use of the mechanism of protein degradation induced byRead More…
A core factor of Protein Degrader molecules is that protein degradants can be designed rationally by selecting ligase molecules and linkers according to the target. The module that binds to E3 ligaseRead More…
Protein Degrader Concept Protein Degraders has become a new model of drug discovery, with the potential to change traditional drug discovery, and may become a new blockbuster therapy. Protein Degraders is aRead More…
It took nearly 20 years for Protein Degrader technology to transform from academia to preclinical and clinical drug development projects. In 2019, Protein Degrader obtained the clinical proof of concept in oncologyRead More…
There are about 514 different protein kinases operating in human cells, accounting for 2.5% of the entire human genome. For scientists who want to use targeted protein degradation (TPD) technology to destroyRead More…
The wide range of application and the great potential in overcoming drug resistance and targeting non-proprietary targets, research and development in Protein Degrader field has been hot in recent years. Protein Degrader,Read More…
Protein Degraders, also named as Proteolysis-Targeting Chimeras, is a new type of drug that is different from antibodies and traditional small molecular inhibitors. It consists of target proteins ligand, linker, and E3Read More…