Human antibodies generated from transgenic animals represent an important, broad and rapidly growing therapeutic class with constantly growing global market. This new trend is based on the use of genetically engineered animals that can produce diverse antibodies with fully human isotypes. Recently, Creative Biolabs has commercialized a brand-new CAMouse™ fully human antibody generation platform to meet the increasing demands in this area. Particularly, we now bring this excellent CAMouse™ VHK strain to worldwide researchers.

Introduction of CAMouse™ VHK Strain

Human antibodies raised from transgenic animals represent an important, broad and fast-growing therapeutic class with constantly expanding global market. This new trend is based on a proven technology of introducing human Ig gene segments to replace endogenous mouse ones. Therefore, these genetically engineered mice can robustly produce antibodies with fully human isotypes, as well as other superior properties such as high specificity, high affinity, good developability, low immunogenicity, etc. These transgenic mice with human immune systems have become an invaluable tool for therapeutic/diagnostic antibody generation.

So far, many different strains of humanized mice have been developed. In addition to conventional heavy-light chain antibodies, Creative Biolabs also provide alternative strains with different characteristics to meet diverse demands and applications. Currently, we can offer an innovative CAMouse™ VHK strain that can produce human antibodies with constant light chain. Compared to standard VHL mouse strain, a single, common, rearranged Vκ & Jκ gene was introduced into the germline of CAMouse™ VHK strain. Hence, the mouse will produce human antibodies only with a constant light chain. Heavy chain repertoire will be diversified as normal. This VHK mouse strain is an excellent choice for bispecific antibody development as well as phage display technology.

Attractive Features of the CAMouse™ VHK Strain Antibody Discovery Service

• Fully human sequence: The biggest challenge to transgenic mice is the introduction of large size human Ig loci. With an exclusive technology that can introduce gene fragment of over 800 kb in one time, the CAMouse™ VHK strain is able to generate fully human antibodies with a diverse adult-like repertoire against a given antigen.
• Potent immune response: With well-designed antigens and immunization plans for each specific case, we will use our insight and expertise to raise superior immune responses in CAMouse™ VHK strain against most antigens.
• Diverse heavy chain repertoire with constant light chain: This unique property makes this mouse strain a powerful toolbox for bispecific antibody development. Besides, it’s perfect compatible to phage display strategy, which helps to eliminate the native VH-VL pair problem.
• Professional tech support: With extensive experience in antibody discovery, our seasoned team of experts are glad to work with you step by step to meet every specific request. We provide professional technical support and troubleshooting throughout the whole process.

If you have interests in the CAMouse™ VHK strain or our CAMouse™ fully human antibody generation platform, please do not hesitate to contact us for more information.

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Please note: we only produce antibodies for research purposes. Our products and services cannot be used directly on humans.