Anti-Microbiome Primary Antibodies

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Creative Biolabs provides a variety of anti-microbiome primary antibodies for the study of disease mechanisms.

Overview

The microbiome is the last human organ to be actively studied. Some bacteria in the gut and skin, which are not currently considered pathogens in the human host, may elicit antibody responses and cause disease in the host. Nonpathogenic (commensal) bacteria have millions of antigens that activate genetically selected B-1 lymphocytes to produce natural antibodies. Bacteria are the best source of anti-carbohydrate antibodies. Specific antibodies against microbial proteins target symbiotic microorganisms commonly present on the surface of the human host, which is important in shaping immune system development and maintaining interactions between the human host and the environment. The relationship of these microbes to disease processes is gradually emerging, and the discovery of anti-microbial antibodies cross-reacting to human tissues suggests a new mechanism of pathogenesis with the potential to design a new therapeutic strategy for a broad spectrum of autoimmune diseases.

Gut microbiome associates with disease through different axes via different mechanisms. Fig.1 Gut microbiome associates with disease through different axes via different mechanisms. (Zhang, 2021)

The Role of Anti-Microbiome Primary Antibodies

Primary antibodies are large Y-shaped glycoproteins (also called immunoglobulins) produced by the immune system in response to foreign substances. They have high affinity and can specifically recognize antigens, so they are widely used in scientific research for protein localization, purification, and quantification. Specific antimicrobial antibodies that respond to human tissues are important and help explain the pathogenesis of autoimmune diseases.

Related Anti-Microbiome Antibody Products

Anti-Microbiome Ab Secondary Antibodies
Anti-Microbiome Ab Isotype Controls

If you are interested in our anti-microbiome primary antibodies products, please contact us for more details.

Reference

  1. Zhang, C.; et al. Consideration of gut microbiome in murine models of diseases. Microorganisms. 2021, 9(5): 1062.

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A. aeolicus LeuT A. australis AaHI A. castellanii A. castellanii cysts A. stephensi Anopheline AflaToxin B1 Aspergillus AflaToxin B1, B2, G1, G2 B. anthracis BclA B. anthracis PA B. burgdorferi OspA B. burgdorferi OspB B. mallei LPS Capsular B. pseudomallei B. pseudomallei Exotoxin B. pseudomallei Protease B. rubescens MBG B. subtilis RNaseY Multiple Bacteria Bordetella FHA C. albicans C. albicans 1,3-Beta-glucan C. albicans Hyphae C. botulinum BoNT/A Heavy Chain C. botulinum BoNT/A Light chain protease C. botulinum BoNT/A Holotoxin

For Research Use Only. Do NOT use in humans or animals.

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