For many years, complement was viewed mainly as a circulating “attack system” that tags microbes and punches holes in their membranes. A recent review in the Journal of Clinical Investigation reframes thisRead More…
Whether you’re studying autoimmune disorders, infectious disease models, tumor immunology, or neurodegeneration, C1q seems to show up in every figure legend, every mechanism diagram, and nearly every pathway conversation. So why isRead More…
Complement and Cancer In 2007, the first truly complement-targeted drug, the anti-C5 monoclonal antibody eculizumab (Eculizumab, Soliris), was approved for the treatment of PNH, and has achieved a revolutionary success, not onlyRead More…
Cancer is a complex, multifactorial disease that evolves through a series of functional capabilities, widely known as the hallmarks of cancer. Among the numerous biological systems influencing these hallmarks, the innate immuneRead More…
The complement system has long been recognized as a central player in innate immunity, defending the host against infections while maintaining tissue homeostasis. Among its components, complement C3 stands as a pivotalRead More…
Although complement was originally described as a powerful defense mechanism against invading pathogens, it can also be activated by tumor-targeting antibodies to kill tumor cells. Antibody and Complement Activation Immunoglobulin (Ig) inductionRead More…
Complement factor B (CFB) inhibitors exert therapeutic effects by specifically binding to factor B, inhibiting abnormal activation of the complement bypass pathway, and controlling intravascular and extravascular hemolysis in paroxysmal sleep hemoglobinuriaRead More…
The immune complement system is a crucial component of the body’s intrinsic immunity, playing roles such as regulating immune responses and clearing pathogens. A growing body of research suggests that the complement system is aberrantlyRead More…
Microglia-neuron interactions regulate brain development, maturation, homeostasis, and disease genesis. The innate immune complement component C1q, produced and secreted by microglia, has brain function specificity. C1q acts as an initiating molecule forRead More…
The complement system is a primary barrier of the innate immune defense system formed by a series of proteins working in a highly coordinated manner to defend against microbial invasion of host tissues. InRead More…