CD35, also known as complement receptor 1 (CR1), plays a crucial role in the complement system. The complement system is part of the immune system that recognizes and removes pathogens, promotes inflammatoryRead More…
Structure of Complement Regulatory Protein Factor H Complement Factor H, also known as Factor H and CFH, is a sialic acid-containing glycoprotein that plays an integral role in regulating the complement-mediated immuneRead More…
Dianthus Therapeutics’ (DNTH) primary asset is DNTH103, a selective monoclonal antibody targeting the active form of complement C1s. The main focus is a me-better version of Sanofi’s already-marketed C1s monoclonal antibody, Sutimlimab.Read More…
Cascade activation of the complement system is one of the key mechanisms of the immune system against pathogenic infections. It is a complex network of plasma proteins, including inflammatory peptides, proteases, andRead More…
The complement system plays a crucial role in the body’s defense against harmful invaders. It is an essential component of the innate immune response, and its end products, C3a and C5a, exertRead More…
Complement is an essential component of the intrinsic immune system, comprising a set of serum-functioning proteasome cascade pathways that play a crucial role in clearing invading pathogens and senescent dying cells. ProteaseRead More…
The complement system is an important part of the innate and adaptive immune system. When activated, it participates in the body’s defense response and immune regulation, including enhancing antibody response, possessing immuneRead More…
Complement, named because it assists antibodies in removing pathogens, is a group of about 20 proteins found in plasma. Complement is mainly derived from the liver or certain cell membrane proteins andRead More…
Bordet, the winner of the 1919 Nobel Prize in Physiology or Medicine, found that when serum was heated to 56°C, it lost its ability to kill bacteria, even though the antibodies inRead More…
The increasing number of clinical diseases involving pathological contributions of the complement system has prompted renewed interest in therapeutic options to modulate this host defense pathway. Based on these findings, the pharmaceuticalRead More…