Complement-targeted therapeutics are gaining momentum across immunology, hematology, nephrology, ophthalmology, neurology, oncology, transplantation, infection-related inflammation, and rare disease research. As the biological understanding of the complement system continues to deepen, more drugRead More…
As complement-targeted drug discovery continues to expand, researchers are placing greater emphasis on one critical question: how can complement biology be measured in a way that is truly relevant to disease mechanismsRead More…
The complement system is an important component of innate immunity, playing a key role in defending against invading pathogens. It consists of approximately 60 soluble and membrane-bound proteins, including core components, receptors,Read More…
Microglia-neuron interactions regulate brain development, maturation, homeostasis, and disease genesis. The innate immune complement component C1q, produced and secreted by microglia, has brain function specificity. C1q acts as an initiating molecule forRead More…
The complement system is a primary barrier of the innate immune defense system formed by a series of proteins working in a highly coordinated manner to defend against microbial invasion of host tissues. InRead More…
Cascade activation of the complement system is one of the key mechanisms of the immune system against pathogenic infections. It is a complex network of plasma proteins, including inflammatory peptides, proteases, andRead More…
Bordet, the winner of the 1919 Nobel Prize in Physiology or Medicine, found that when serum was heated to 56°C, it lost its ability to kill bacteria, even though the antibodies inRead More…