Introduction: The Growing Need for Scalable Exosome Manufacturing Exosomes, small extracellular vesicles ranging from 30 to 150 nanometers, have gained significant traction in biomedical research and clinical development due to their remarkableRead More…
Introduction: The Growing Importance of Exosome Research Almost every cell type secretes exosomes which are extracellular vesicles measuring between 30 and 150 nanometers in diameter. Exosomes perform essential roles in cellular interactionRead More…
Melanoma is one of the most aggressive types of skin cancer, characterized by rapid progression and a high metastasis rate, with a median survival of only 3 to 11 months. Current melanomaRead More…
Small extracellular vesicles (sEVs) are nanoscale vesicles. Death receptor 5 (DR5) mediates exogenous apoptosis. Recently, scientists published a paper in Science Advances where they designed single-chain variable fragments (scFvs) that agonize DR5,Read More…
Although Wnt proteins are hydrophobic glycoproteins, they are capable of long-range signaling. Researchers at The Ottawa Hospital Research Institute in Canada discovered that Wnt7a is secreted as extracellular vesicle (EV)-associated proteins afterRead More…
Diabetic retinopathy is one of the early complications of diabetes. The disease is serious and can lead to blindness in its advanced stages. Currently, treatments for diabetic retinopathy are mainly limited toRead More…
Therapeutic approaches based on extracellular vesicles (EVs) are attracting significant attention in drug delivery, immunotherapy, and regenerative medicine. However, the clinical translation of EVs is hindered by challenges such as limited yield,Read More…
On September 2, 2024, Nature Materials published a study titled “Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery.” This research challenges traditional views by revealing that tumor-secreted exosomesRead More…
Extracellular vesicles (EVs), including exosomes, encapsulate DNA, RNA, and proteins within a phospholipid bilayer. These vesicles deliver their lumenal cargo to the cytoplasm of recipient cells, influencing immune cell function. This impactRead More…
Extracellular vesicles (EVs), including exosomes, are cell-derived nano or micrometer-sized monolayer or multilayer membrane structures. EVs contain bioactive cargoes such as nucleic acids, lipids, proteins, and carbohydrates, and play a key roleRead More…