With years of experience in the field of molecular and cell biology research, Creative Biolabs is capable of supporting all aspects of your exosome research. Equipped with state-of-art tools and technologies, we offer the most comprehensive exosome-related research services, ranging from isolation and characterization to cargo profiling and engineering, for a better understanding of their physiological functions, for the discovery of clinical biomarkers, and for engineering of exosomes for therapeutic applications.
Exosomes are 30-150 nm tiny vesicles secreted by most cell types in vivo and in vitro. They are found in all body fluids including plasma, serum, saliva, urine, amniotic fluid, malignant ascite fluids, and cultured medium of cell cultures. Exosomes contain various molecular constituents of their cell of origin, including proteins and RNA. Evidence has shown that exosomes act as many different roles and functions including eradication of obsolete molecules, intercellular communication, antigen presentation, dissemination of oncogenes from tumor cells, and spread of pathogens such as prions and viruses from one cell to another.
Depending on the cell of tissue of origin, exosomes act as many different roles and functions including eradication of obsolete molecules, intercellular communication, antigen presentation, programmed cell death, dissemination of oncogenes from tumor cells, and spread of pathogens, such as prions and viruses from one cell to another, and transfer of tumorigenic proteins, mRNA and miRNA. For example, exosomes from certain cells of the immune system, such as dendritic cells and B cells, containing immunologically active substance can transfer molecules from one cell to another via membrane vesicle trafficking, thereby mediating adaptive immune responses to pathogens and tumors.
In view of the function and/or physiology of exosomes in metabolism activity, they are used for diagnosis and treatment of disease, and as drug delivery vehicles. The presence of distinct subsets of microRNAs within exosomes and other extracellular vesicles (EVs) are secreted depend upon the tumour cell type. Hence, exosomal RNA may serve as biomarkers for early detection of certain cancer types. Furthermore, exosomes can encapsulate drug molecules and deliver them into target tissue.
Fig.1 Exosomes and other extracellular vesicles. (Contreras-Naranjo, 2017)
Creative Biolabs offers a comprehensive array of exosome research services to advance your brilliant exosomal research. Both individual service modules and full services packages are available. If you can’t find your interest program on exosome service list, please contact us to discuss your project and create a custom quote.