The blood-brain barrier (BBB) poses a significant challenge to the systemic delivery of mRNA to diseased neurons.While extracellular vesicles (EVs) derived from leukocytes can traverse the BBB, efficiently loading lengthy mRNAs intoRead More…
Self-Stimulating Release Hydrogel Enhances the Therapeutic Effect of MSC-EVs on Alzheimer’s Disease
Extracellular vesicle (EV)-based therapeutic approaches still pose challenges in clinical application due to their rapid clearance, limited residence, and low yield. Although hydrogels possess the ability to impede physiological clearance and increaseRead More…
Entry and Exit of Extracellular Vesicles into and from the Blood Circulation
Extracellular vesicles (EVs) are biological nanoparticles that mediate short- and long-distance intercellular communication, delivering bioactive payloads. Short-distance communication occurs in the interstitium, while long-distance communication necessitates transport through the blood circulation toRead More…
Vesiclepedia 2024 – Extracellular Vesicles and Particles Database Update
Vesiclepedia (http://www.microvesicles.org) stands as a comprehensive, web-based database, offering a compilation of DNA, RNA, proteins, lipids, and metabolites that have been identified or associated with extracellular vesicles (EVs) and extracellular particles (EPs).Read More…
Creating Designer Engineered Extracellular Vesicles for Diverse Ligand Display, Target Recognition, and Controlled Protein Loading and Delivery
Effective and targeted drug delivery remains a significant challenge in modern medicine. Researchers are employing biochemical engineering approaches to repurpose extracellular vesicles (EVs) as drug delivery vehicles. Studies have demonstrated that displayingRead More…
Therapeutic Potential in Rheumatic Diseases of Extracellular Vesicles Derived from Mesenchymal Stromal Cells
A recent review was published in Nature Reviews Rheumatology delves into the promising therapeutic applications of mesenchymal stromal cell extracellular vesicles (EVs) in rheumatic diseases. Rheumatic diseases comprise a diverse range ofRead More…
Identifying of Scaffold Proteins to Enhance Endogenous Engineering of Extracellular Vesicles
Extracellular vesicles (EVs) have emerged as a promising avenue for advanced drug delivery. One effective strategy for loading these EVs with desired cargo involves genetically fusing a target protein to a scaffoldRead More…
Engineered RNA Secretion Solutions for Live Cell Monitoring and RNA Delivery
Systems featuring programmable RNA molecule export capabilities hold the potential for non-destructive cellular dynamics monitoring and efficient RNA delivery to engineered cells. In a recent breakthrough, Michael B. Elowitz and Felix HornsRead More…
The Value of Glycosylation Modifications on Extracellular Vesicles in Vesicle Isolation Analysis and Clinical Detection
Recent studies have revealed that extracellular vesicles (EVs) surface molecules are often accompanied by glycan or glycosylation modifications. Researchers from the Institute of Chemistry at the Slovak National Academy of Sciences haveRead More…
Extracellular Vesicles in Fatty Liver Promote a Metastatic Tumor Microenvironment
Non-alcoholic fatty liver disease (NAFLD) is strongly linked to various cancers, including liver, breast, prostate, pancreatic, and colorectal cancer, surpassing its association with obesity alone. Patients with fatty liver disease exhibit aRead More…