Protein Degrader technology, by linking E3 ubiquitin ligase to the target protein, leads to the ubiquitin modification of the target protein which is broken down into peptides and amino acids by proteasome.Read More…
New lung cancer diagnoses and deaths have decreased as a result of reduced smoking and advances in early screening and treatment. However, lung cancer remains the leading cause of cancer deaths, accountingRead More…
Protein degradation targeted chimera (Protein Degrader) can efficiently degrade disease-causing proteins to treat varieties of diseases and has been widely investigated by global researchers. Despite of its promising prospects, the pharmacokinetic behaviorRead More…
Glioma is a primary intracranial malignant tumor originating from glial cells or progenitor cells, accounting for 25.5% of central nervous system tumors. Clinically, the treatment of glioma mainly depends on surgical resection,Read More…
Acute lymphoblastic leukemia (ALL) is a common disease. B-ALL and T-ALL account for 85% and 15% of the two lymphatic lineages of ALL, respectively, but patients with T-ALL have poor life qualityRead More…
In the past 20 years, Protein Degrader has ushered in a period of rapid development, especially since the successful degradation of BET protein by dBET1 Protein Degrader with pomalidomide as the ligandRead More…
Induced degradation of target proteins is a new concept in drug discovery. For eukaryotes, the ubiquitin-proteasome system is the main pathway of intracellular protein degradation, which participates in more than 80% ofRead More…
Protein Degrader (Proteolysis-Targeting Chimera) technology, by linking E3 ubiquitin ligase to the target protein, leads to the ubiquitin modification of the target protein, which is broken down into peptides and amino acidsRead More…
Targeting tumor cell apoptosis and angiogenesis Apoptosis (or programmed cell death) is an evolutionarily conservative process that maintains tissue homeostasis under cellular stress, DNA damage and immune surveillance. However, cancer cells canRead More…
The occurrence and development of cancer is a complex process, which is characterized by continuous proliferation signals, avoidance of growth inhibitors, resistance to cell death, induction of angiogenesis, activation of invasion andRead More…