Endocrinology

Introduction of Endocrinology

Endocrinology encompasses the study of the endocrine system, its associated diseases, and hormone secretions. It delves into the intricate interplay between developmental events, metabolic processes, and sensory perception influenced by hormones. The endocrine system comprises glands scattered throughout the body, releasing hormones directly into the bloodstream, thus considered ductless glands. Endocrine disorders stem from imbalances in hormone secretion or reception, manifesting as hypo- or hypersecretion. These conditions are often multifaceted, involving feedback mechanisms within the endocrine system. Endocrinology addresses the complexity of these disorders, aiming to understand and manage the intricate hormonal dynamics underlying various physiological and pathological processes.

BsAbs in Endocrinology

Bispecific antibodies (BsAbs) represent an innovative approach with dual binding sites, offering distinct advantages over monoclonal antibodies by expanding therapeutic possibilities. With over a bunch of BsAbs currently under clinical evaluation, their versatility in addressing human endocrinology disorders is evident. For instance, a dual GHR-PRLR targeting antibody demonstrates promise in antagonizing the prolactin receptor (PRLR) and growth hormone receptor (GHR), inhibiting the PRLR signaling axis. This preclinical study underscores the potential of GHR/PRLR BsAb as a viable therapeutic strategy for breast cancer treatment, illustrating the growing excitement surrounding BsAbs in the realm of endocrinology therapy.

Creative Biolabs provides a diverse array of more than 80 BsAb options to support research in endocrinology therapy. Customization services are available to tailor bispecific antibodies for endocrinology conditions to meet specific research needs.

Fig. 1 Illustration of endocrine system.¹ Distributed under CC BY 3.0, from Wiki, without modification.