Tandem scFvs are a class of bispecific antibody fragments. Two or more moieties of scFv string together to form tandem scFv, which has 1+1 (+1…) antigen-binding. scFvs are fused by a helical linker or a flexible linker. The format of tandem scFvs can be defined by the orientation of the VH and VL domain in the two individual scFvs (i.e., VL-VH or VH-VL) and the connecting linker. Without Fc domain, the smaller size of tandem scFv gives it a short half-life. Meanwhile, it also ensures a closer proximity to two or more targets.
The format of tandem scFvs has been extensively used in cancer immunotherapy.
In addition to high-quality pre-made tandem scFv products, we also provide Tandem scFv Generation Service for customization requirement.
Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.