Infectiology

Introduction of Infectiology

Infectiology, a specialized field in medicine, is devoted to the examination and management of infections. An infectiology expert delves into identifying the underlying factors of a malady, be it bacteria, viruses, parasites, fungi, or prions. Subsequent to identifying the causative agent, a range of tests will be conducted to pinpoint the most effective medication for treatment. In addressing infections, an array of antimicrobial substances will be employed, tailored to combat specific pathogens.

BsAbs in Infectiology

BsAbs are designed to target two unique epitopes or antigens, enabling them to bind either to two distinct proteins or to two separate sites on the same protein. Several BsAbs have been investigated for their potential in combating infectious diseases. For example, a BsAb that targets both the RBS of the NPC1 protein and a conserved surface-exposed epitope on the EBOV glycoprotein has exhibited efficacy in neutralizing all known strains of the Ebola virus. This BsAb facilitates the delivery of viral particles to endosomes and offers post-exposure protection against multiple strains of EBOV in mouse models. Moreover, modifying the hinge domain of a BsAb designed for HIV-1 has shown potential in enhancing its ability to neutralize the virus and provide protective effects in HIV-1-infected humanized mice by enhancing the flexibility of the Fab domain.

Creative Biolabs offers extensive selections of over a hundred BsAb options tailored to bolster research in infectious disease therapy. Customization services cater to specific research requirements in infectious disease conditions. We stand ready to support your scientific and medical research initiatives.