Scfv fragments are a class of units that are commonly used to generate BsAbs. Besides the formats widely studied, there are numerous other scFv-based bispecific fragments.
scFv-CH1/CL: Two scFv fragments against different epitopes are linked to CH1/CL domain separately. The CH1 and CL can form heterodimers. The BsAb of this format has 1+1 antigen-binding valency. (Cat. BSCC)
scFv-CH3: This format is a fusion protein of scFv fragments to the CH3 domains. The knobs-into-holes mutations in CH3 facilitate the formation of heterodimer. The addition of CH3 domains extends the half-life of the bispecific fragments. (Cat. BSFC)
Miniantibody: Miniantibody is a type of dimeric bispecific fragments. It contains two scFvs connected by intra-chain bond of two peptides. Miniantibody combines two specificities with 1+1 antigen-binding valency. (Cat. MNAB)
scFv-Fc: scFv-Fc is a bispecific, bivalent molecule which is developed by fusing scFvs with different specificity to each Fc chain. The knobs-into-holes mutations in Fc force the formation of heterodimer. scFv-Fc have similar properties with conventional IgGs. (Cat. BSCFV)
scFv-Fc-scFv (Intrabody): scFv-Fc-scFv is generated by fusing two groups of bivalent scFv fragments to the N- and C-terminus of the Fc region. It is a bispecific, tetravalent homodimer with 2+2 antigen-binding valency. (Cat. BSTF)
In addition to high-quality pre-made scFv-based bispecific fragment products, we also provide ScFv Fragments BsAb Generation Service for customization requirement.
Browse scFv-based Bispecific Fragments based on alphabetical listing:
A
B
C
D
E
F
G
H
I
K
M
N
O
P
T
V
Welcome! For price inquiries, we will get back to you as soon as possible.
INQUIRYSERVICES
PRODUCTS
PLATFORMS