scFv-based Bispecific Fragments

Scfv fragments are a class of units that are commonly used to generate BsAbs. Besides the formats widely studied, there are numerous other scFv-based bispecific fragments.

scFv-CH1/CL: Two scFv fragments against different epitopes are linked to CH1/CL domain separately. The CH1 and CL can form heterodimers. The BsAb of this format has 1+1 antigen-binding valency. (Cat. BSCC)
scFv-CH3: This format is a fusion protein of scFv fragments to the CH3 domains. The knobs-into-holes mutations in CH3 facilitate the formation of heterodimer. The addition of CH3 domains extends the half-life of the bispecific fragments. (Cat. BSFC)
Miniantibody: Miniantibody is a type of dimeric bispecific fragments. It contains two scFvs connected by intra-chain bond of two peptides. Miniantibody combines two specificities with 1+1 antigen-binding valency. (Cat. MNAB)
scFv-Fc: scFv-Fc is a bispecific, bivalent molecule which is developed by fusing scFvs with different specificity to each Fc chain. The knobs-into-holes mutations in Fc force the formation of heterodimer. scFv-Fc have similar properties with conventional IgGs. (Cat. BSCFV)
scFv-Fc-scFv (Intrabody): scFv-Fc-scFv is generated by fusing two groups of bivalent scFv fragments to the N- and C-terminus of the Fc region. It is a bispecific, tetravalent homodimer with 2+2 antigen-binding valency. (Cat. BSTF)

In addition to high-quality pre-made scFv-based bispecific fragment products, we also provide ScFv Fragments BsAb Generation Service for customization requirement.

Background

Our products and services are for research use only, and not for use in diagnostic or therapeutic procedures.