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Triple Body

Triple Body (also known as Tribody, not the scFv triple-body) is a class of bispecific antibody fragments. It is multifunctional rAb derivative, combination of Fab with additional entities. Triple Bodies utilize Fab fragment as scaffold, in which the Fd fragment of HC and LC can heterodimerize naturally in vivo, and additional functions can be incorporated on the scaffold, such as scFv, cytokines, etc. Thus, the Triple Bodies can lead to 3x1 (trispecific, trivalent), 2+1 (bispecific, bivalent+monovalent), trivalent or 1+1 (bispecific, bivalent) molecule, as well as immunocytokines, immunotoxins, enzyme fusions, etc.

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