Description
Recombinant HEK293 cell line expressing a full length human CD137 (NM_003811). The NF-kappaB luciferase reporter construct is stably integrated into the genome. The firefly luciferase gene is controlled by 4 copies of NF-kappaB response element located upstream of the TATA promoter. Following activation by human CD137 ligand, NF-kappaB transcription factors bind to the DNA response elements to induce transcription of the luciferase gene.
Applications
Screen for activators or inhibitors of CD137 signaling in a cellular context Characterize the biological activity of CD137 and its interactions with ligands
Datasheet