For Research Use Only | Not For Clinical Use
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[Cat#: IO-C-HMM100]
Product Type
Supporting Reagents
Product Overview
This product is used to reconstitute LAL and render the reagent insensitive to (1→3)-β-D-glucan interference by effectively blocking the factor G pathway of the endotoxin clotting cascade.
[Cat#: IO-C-HMM101]
Product Type
Supporting Reagents
Product Overview
This product is used for the dilution of TLRpure LPS and solubilisation of endotoxin-free reagents.
[Cat#: IO-C-HMM102]
Product Type
Supporting Reagents
Product Overview
PBS with EDTA is used to detach and dissociate clumped cells in cell culture applications.
[Cat#: IO-C-HMM103]
Product Type
Supporting Reagents
Product Overview
Solubilisation and storage buffer for DNA, diluting 1: 100 with sterile endotoxin-free water
[Cat#: IO-C-HMM104]
Product Type
Supporting Reagents
Product Overview
β-1,3-Glucans can produce false positive results in LAL assays. Some examples of glucan sources include yeast and cellulosic materials including hemodialysis filters. Our β-G-Blocker may be used with any of our LAL assays.
[Cat#: IO-C-HMM105]
Product Type
LAL Reagents
Product Overview
LAL reagent water(LRW) is specially processed water intended for reconstitution of LAL reagents and CSE, and to dilute samples and standards for LAL assays. Not for human or animal injection. LRW contains less than 0.001 EU/mL endotoxin and less than 1.56 pg/mL glucan.
[Cat#: IO-C-HMM106]
Product Type
LAL Reagents
Product Overview
LAL reagent water(LRW) is specially processed water intended for reconstitution of LAL reagents and CSE, and to dilute samples and standards for LAL assays. Not for human or animal injection. LRW contains less than 0.001 EU/mL endotoxin and less than 1.56 pg/mL glucan.
[Cat#: IO-C-HMM107]
Product Type
LAL Reagents
Product Overview
LAL reagent water(LRW) is specially processed water intended for reconstitution of LAL reagents and CSE, and to dilute samples and standards for LAL assays. Not for human or animal injection. LRW contains less than 0.001 EU/mL endotoxin and less than 1.56 pg/mL glucan.
[Cat#: IO-C-HMM108]
Product Type
LAL Reagents
Product Overview
LAL reconstitution buffer is used for testing electrolytes, strongly buffered solutions (especially bicarbonate buffers), and solutions for which it is difficult to adjust pH into the required range. It is also available with a pH indicator for gel-clot applications.
[Cat#: IO-C-HMM109]
Product Type
LAL Reagents
Product Overview
LAL reagent reservoirs used with multi-channel pipettors ideal for endotoxin testing.
[Cat#: IO-C-HMM110]
Product Type
LAL Reagents
Product Overview
MgCl2 can be used as the sample diluent when attempting to overcome inhibitory chelation effect. Examples of samples which chelate divalent cations include heparin and EDTA. MgCl2 may be used to prepare samples for any LAL assay.
[Cat#: IO-C-HMM111]
Product Type
LAL Reagents
Product Overview
Bulk kinetic turbidimetric reconstitution buffer is provided for rehydration of the LAL reagent and should be used with corresponding Kit.
[Cat#: IO-C-HMM112]
Product Type
LAL Reagents
Product Overview
Gel clot LAL assay reagent contains no excipients, has strong anti-interference ability, high clarity, solid gel and wide sensitivity range. It is recommended to stand in a constant temperature 37° C water bath, and the process should be handled gently. Before use, the sensitivity of the reagent should be checked first, and the sample should be tested after the interference pre-experiment.
[Cat#: IO-C-HMM113]
Product Type
LAL Reagents
Product Overview
This product is filled in the standard horseshoe crab test reaction tube, sealed under vacuum, low moisture content, stable and reliable reagent quality. The diameter of the test tube is the same as the international standard. It is suitable for water bath or dry heat thermostat. It is safe and fast to use. It does not need to be dissolved by water. It can be directly loaded and easy to operate.
[Cat#: IO-C-HMM114]
Product Type
LAL Reagents
Product Overview
This product is filled in a vial, sealed under vacuum, with low moisture content and stable and reliable reagent quality. When using, add appropriate amount of endotoxin free water, safe and fast, easy to operate.
[Cat#: IO-C-HMM115]
Product Type
LAL Reagents
Product Overview
This product is used for chromogenic LAL assay.
[Cat#: IO-C-HMM116]
Product Type
LAL Reagents
Product Overview
This product is designed according to the principle that the reaction time required to detect the chromaticity of the reaction solution reaches a certain preset absorbance is proportional to the endotoxin concentration in the reaction liquid, and is used for drugs, biological products,medical instruments for human and animal injection and endotoxin testing of end products in vitro.
[Cat#: IO-C-HMM117]
Product Type
LAL Reagents
Product Overview
The experimental principle, conditions and methods of kinetic chromogenic LAL assay reagent are exactly the same as the dynamic color development method.
[Cat#: IO-C-HMM118]
Product Type
LAL Reagents
Product Overview
This product is equipped with azo nitride dyeing agent, which has high sensitivity and can avoid the interference of the color of the colored specimen on the horseshoe crab test. It is equipped with an endotoxin-free test tube, which is convenient for incubation in a water bath. The test results can be read by a spectrophotometer or a common microplate reader. It can be applied to the sample background color is light yellow, such as plasma, serum samples.
[Cat#: IO-C-HMM119]
Product Type
LAL Reagents
Product Overview
This product is used for turbidimetric LAL assay.
[Cat#: IO-C-HMM120]
Product Type
LAL Reagents
Product Overview
The experimental principle, conditions and methods of microscale kinetic turbidimetric LAL assay reagent are identical to those of the turbidity horseshoe crab reagent. It detects the change in the absorbance value of the reaction solution, and when the absorbance value rises to a certain preset value, the instrument automatically records the reaction time. It automatically calculates the endotoxin concentration of the test sample using a standard curve of reaction time versus standard endotoxin concentration.
[Cat#: IO-C-HMM121]
Product Type
LAL Reagents
Product Overview
The specific LAL assay reagent is also called the G factor horseshoe crab reagent/specific endotoxin detection reagent, TAL-ES-Test. The specific horseshoe crab reagent is a G-factor bypass inhibitor added to the formula of the horseshoe crab reagent, so that the horseshoe crab reagent does not produce a false positive reaction to the (1,3)β-D-glucan, and the detection result is more accurate and reliable.
[Cat#: IO-C-HMM122]
Product Type
LAL Reagents
Product Overview
Chromo-LAL lysate is lyophilized with substrate reagent and buffers. It is optimized for the kinetic chromogenic LAL test method in microplate readers. Chromo-LAL is a buffered, stable and robust lysate, suitable for quantitative testing of a wide range of samples.
[Cat#: IO-C-HMM123]
Product Type
LAL Reagents
Product Overview
Chromogenic endotoxin testing reagents is a versatile quantitative reagent that is used to perform kinetic or endpoint assays. It is a sensitive and flexible reagent that can be used for testing in compliance with the USP, EP and JP bacterial endotoxins test chapter.
[Cat#: IO-C-HMM124]
Product Type
LAL Reagents
Product Overview
Turbidimetric formulation lysate is used to quantify endotoxin in kinetic turbidimetric tests.
[Cat#: IO-C-HMM125]
Product Type
LAL Reagents
Product Overview
This is an endotoxin-free solution containing human serum albumin (HSA) that is capable of extracting endotoxins that cannot be extracted in water or saline solution.
[Cat#: IO-C-HMM126]
Product Type
LAL Reagents
Product Overview
The ES buffer is an endotoxin-specific buffer that is ideal for untreated LAL. The ES buffer works by adding a large amount of carboxymethylated curdlan (CMC) to LAL, thus preventing the activation of LAL by glucan. The presence of large amounts of glucan does not interfere with the quantitation of endotoxin.
[Cat#: IO-C-HMM127]
Product Type
Inhibitors
Product Overview
Demethoxycurcumin (DMC) is a natural demethoxy derivative of curcumin with anti-inflammatory and anti-cancer properties. DMC suppresses cell proliferation, migration and invasion in cancer cells. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits lipopolysaccharide induction of iNOS by blocking NF-κ activation. It also has been shown to inhibit energy metabolic and oncogenic signaling pathways through AMPK activation. In addition it is a potent inhibitor of P-Type ATPases. Shown to have neuroprotective properties. It also has anti-plasmodial activity.
[Cat#: IO-C-HMM128]
Product Type
Inhibitors
Product Overview
Nafamostat mesylate is a cell permeable broad spectrum potent and reversible synthetic serine protease inhibitor and kallikrein inhibitor in vitro and in vivo.
[Cat#: IO-C-HMM129]
Product Type
Inhibitors
Product Overview
Same activities as rosaglitazone but different formulation. Antidiabetic, hypoglycemic agent. Potent and selective peroxisome proliferator-activated receptor γ (PPAR-γ) agonist. Potent insulin sensitizing agent binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. Ameliorates insulin resistance. Improves blood pressure and vascular function. Enhances proliferation of endogenous neural progenitor cells (NPCs). Anti-inflammatory compound. Has controversial therapeutic effects on the cardiovascular system. Promotes adipocyte differentiation of mesenchymal stem cells (MSCs).
[Cat#: IO-C-HMM130]
Product Type
Inhibitors
Product Overview
Antibiotic against gram-positive bacteria, particularly staphylococcus and clostridia.
[Cat#: IO-C-HMM131]
Product Type
Inhibitors
Product Overview
Cephalochromin inhibits NO production by activated macrophages.
[Cat#: IO-C-HMM132]
Product Type
Inhibitors
Product Overview
This product shows cytotoxic, teratogenic, mutagenic and genotoxic properties by DNA intercalation. Induces several types of DNA damage, including oxidative DNA damage, single-stranded DNA breaks (SSB) and double-strand, through AOH-induced ROS production and interaction with DNA topoisomerase. Inhibits the activity of topoisomerase IIα in mammalian cells. Induces cell growth arrest in G2/M phase. GSK-3β inhibitor (sub-μM IC50 values). Antiviral activity (herpes simplex). Hepatitis C NS3-4A protease inhibitor. Induces cytochrome P450 1A1 expression and apoptosis in mouse hepatoma cells.
[Cat#: IO-C-HMM133]
Product Type
Inhibitors
Product Overview
Functional ARX inhibitor. Enhancer of GABAA signaling. Shown to promote the in vivo conversion of pancreatic α cells into functional β-like cells through enhanced GABA signaling and may have potential as a therapeutic for diabetes.
[Cat#: IO-C-HMM134]
Product Type
Inhibitors
Product Overview
Inhibits production of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) and nitric oxide (NO).
[Cat#: IO-C-HMM135]
Product Type
Inhibitors
Product Overview
Ganglioside GM1 is a major sialoglycolipid of neuronal membranes that modulates calcium homeostasis and which is important for neuronal plasticity and repair mechanisms. It binds to cholera toxin B subunit, resulting in stimulation of adenylyl cyclase in a wide variety of cell types. After cholera toxin binds to membrane associated Monosialoganglioside GM1, the A subunit of cholera toxin is translocated to the cell interior, where it catalyzes the ADP ribosylation of the membrane associated Gs subunit of adenylyl cyclase. In addition, binding of cholera toxin to monosialoganglioside GM1 causes translocation of NF-κB and activation of dendritic cells. E. coli heat-labile enterotoxin (LT) is structurally and functionally similar to cholera toxin and binds GM1 as well. GM1 has also been shown to improve Parkinson's disease symptoms and slow it's progression.
[Cat#: IO-C-HMM136]
Product Type
Inhibitors
Product Overview
FSL-1 (Pam2CGDPKHPKSF) is a synthetic lipoprotein that represents the N-terminal part of the 44kDa lipoprotein LP44 of Mycoplasma salivarium.
[Cat#: IO-C-HMM137]
Product Type
Inhibitors
Product Overview
R-FSL-1 (R-Pam2CGDPKHPKSF) is a synthetic lipoprotein that represents the N-terminal part of the 44kDa lipoprotein LP44 of mycoplasma salivarium.
[Cat#: IO-C-HMM138]
Product Type
Inhibitors
Product Overview
This product is nitric oxide (NO) donor and generates both superoxide anion and nitric oxide that spontaneously form peroxynitrite.
[Cat#: IO-C-HMM139]
Product Type
Inhibitors
Product Overview
AICAR is a cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCs in vitro.
[Cat#: IO-C-HMM140]
Product Type
Inhibitors
Product Overview
Pioglitazone, reduces peripheral insulin resistance, leading to a reduction of blood-glucose concentration.
[Cat#: IO-C-HMM141]
Product Type
Inhibitors
Product Overview
GYY 4137 is a water-soluble, slow-releasing hydrogen sulfide (H2S) donor. When given intravenously, it demonstrates vasodilator and anti-hypertensive activity in rats, in either the acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models.1 Intravenous GYY 4137 also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation.
[Cat#: IO-C-HMM142]
Product Type
Inhibitors
Product Overview
Rosiglitazone is a potent and selective PPARγ agonist (EC50 = 60 nM); exhibits no activity at PPARα and PPARβ. Promotes differentiation of pluripotent C3H10T1/2 stem cells into adipocytes. Also promotes differentiation of urothelial organoids in combination with erlotinib. Ameliorates endotoxin-induced organ damage in conscious rats.
[Cat#: IO-C-HMM143]
Product Type
Inhibitors
Product Overview
Asiaticoside, the major active principle of centella asiatica, prevents ultraviolet A-dependent photoaging by suppressing ultraviolet A-induced reactive oxygen species production. It also decreases DNA binding by MITF.
[Cat#: IO-C-HMM144]
Product Type
Inhibitors
Product Overview
Monosodium urate (crystals) can act as endogenous danger signals that stimulate the innate immune system to produce inflammatory cytokines such as IL-1β.
[Cat#: IO-C-HMM145]
Product Type
Inhibitors
Product Overview
NLRP3/NALP3 inflammasome activator. Specially crystallized and tested for biological activity. Stimulates the caspase-1 activating NLRP3/NALP3 inflammasome, resulting in the production of active IL-1beta and IL-18.
[Cat#: IO-C-HMM146]
Product Type
Inhibitors
Product Overview
Most commonly used phorbol ester. Causes an extremely wide range of effects in cells and tissues. Very potent mouse skin tumor promoter. Inhibits apoptosis induced by Fas, but induces apoptosis in HL-60 promyelocytic leukemia cells.
[Cat#: IO-C-HMM147]
Product Type
Inhibitors
Product Overview
Citrinin is a hepato-nephrotoxic mycotoxin. It can be produced by several filamentous fungi genera of Monauscus, Aspergillus, and Penicillium, which is commonly found as a contaminant in stored grains, foods, feedstuffs and also in biological fluids.
[Cat#: IO-C-HMM148]
Product Type
Inhibitors
Product Overview
Rutin trihydrate is a bioflavonoid, which may play a key role in the functioning of capillaries.
[Cat#: IO-C-HMM149]
Product Type
Inhibitors
Product Overview
Vinpocetine is a phosphodiesterase inhibitor, selective for PDE1 (IC50 = 21 μM). Also blocks voltage-gated Na+ channels.
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